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Cat. No.: HY-184055

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NMDA receptor antagonist-12

NMDA receptor antagonist-12 (Example 17) is an antagonist of NMDA receptors containing the NR2B subunit. NMDA receptor antagonist-12 exerts antagonistic effects on NMDA receptors containing the NR2B subunit and blocks the intracellular Ca²⁺ influx mediated by these receptors. NMDA receptor antagonist-12 can be used in research related to diseases such as depression, bipolar disorder, migraine, and pain.

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CAS No.: 2643356-08-3
Formule: C₁₈H₁₇F₃N₂O₃
Masse moléculaire:366.33

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Please store the product under the recommended conditions in the Certificate of Analysis.

NMDA receptor antagonist-12 Chemical Structure

CAS No.: 2643356-08-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

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Chemical Information

CAS No. 2643356-08-3
Masse moléculaire 366.33
Formule C₁₈H₁₇F₃N₂O₃
SMILES

C[C@@H]([C@H](CC1=O)O)N1CC2=CN=C(OC3=C(C=C(C=C3)C(F)F)F)C=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Ca²⁺ Staining Technique
Ca²⁺ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca²⁺ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Ikeda S, et al. Heterocyclic nmda antagonists. WO2021094832A1. WIPO; 2021 May 20.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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