NS-8
NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence.
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- CAS No.: 186033-14-7
- Formule: C12H10FN3
- Masse moléculaire:215.23
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[1]
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Dosage:1, 3 and 10 mg/kg
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Administration:Intraduodenal administration, intravenous injection
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Result:Intraduodenal administration: increased the bladder capacity without affecting the MBCP (bladder contraction pressure).
Intravenous injection: inhibited the IVBCs (isovolumetric bladder contractions) in a dose-dependent manner without affecting the amplitude.
Suppressed the increase in the pelvic afferent discharge frequency and inhibited the increase in intravesical pressure.
Chemical Information
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CAS No. 186033-14-7
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Masse moléculaire 215.23
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Formule C12H10FN3
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SMILES
CC1=C(C2=C(F)C=CC=C2)NC(N)=C1C#N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NS-8 Related Classifications
HY-147383 Related Classifications
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