Propiolamide
Based on 1 Customer Validation
Propiolamide is a monooxygenase (MMO) system activator and glutathione peroxidase 4 (GPX4) inhibitor. Propiolamide induces ROS production through interaction with the MMO system. Propiolamide promotes the accumulation of intracellular cytotoxic lipid peroxides and induces ferroptosis. Propiolamide induces programmed cell death via the apoptosis pathway. Propiolamide can be used in cancer research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 7341-96-0
- Formule: C3H3NO
- Masse moléculaire:69.06
-
Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
-
Apoptosis Compound Library
HY-L003
-
Immunology/Inflammation Compound Library
HY-L007
-
Metabolism/Protease Compound Library
HY-L012
-
NF-κB Signaling Compound Library
HY-L014
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Aging Compound Library
HY-L034
-
Antioxidant Compound Library
HY-L037
-
Oxygen Sensing Compound Library
HY-L045
-
Ferroptosis Compound Library
HY-L051
-
Anti-Cancer Metabolism Compound Library
HY-L083
-
Cuproptosis Compound Library
HY-L133
-
Metabolic Enzyme Compound Library
HY-L146
-
Cell Death Library
HY-L162
-
Anti-Ovarian Cancer Compound Library
HY-L173
-
Radioprotector Library
HY-L178
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Structurally Diverse Fragment Library
HY-L187
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
High-Throughput Bioactive Compound Library
HY-L205
-
Lactylation Compound Library
HY-L249
-
Alkyne Compound Library
HY-L258
Activité biologique
|
GPX4 |
Propiolamide (14 mM; 0-30 min) induces microsomal monooxygenase-mediated reactive oxygen species production in CYP3A4/CPR/Cyt c and CYP3A4/NADPH systems[1].
Propiolamide (38 μM) inhibits the activity of glutathione peroxidase 4 derived from bovine red blood cells by 46%[1].
Propiolamide (30-50 μM; 12 h) induces apoptosis in HeLa cells in a concentration-dependent manner in vitro. After 12 hours of treatment, the proportion of total apoptotic cells reaches 7.13% at 30 μM and 10.33% at 50 μM[1].
Propiolamide (50 μM; 12 h) promotes lipid peroxidation in HeLa cells, which is a key marker of ferroptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HeLa human cervical cancer cells
-
Concentration:30 μM; 50 μM
-
Incubation Time:12 h
-
Result:Increased total apoptotic cells (early + late stage) from 4.30% (untreated control) to 7.13% at 30 μM.
Further increased total apoptotic cells to 10.33% at 50 μM.
Chemical Information
-
CAS No. 7341-96-0
-
Appearance Solid
-
Masse moléculaire 69.06
-
Formule C3H3NO
-
Color Off-white to light yellow
-
SMILES
O=C(C#C)N
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Pureté et documentation
-
Fiche technique (270 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz