CASK
CASK is a calcium/calmodulin-dependent serine/threonine kinase that belongs to the membrane-associated guanylate kinase scaffold family, combining an N-terminal catalytic domain with PDZ, SH3, and guanylate kinase-like interaction modules. Unlike classical CaMKs, its activity is largely calcium-independent. CASK localizes to synaptic and epithelial junctions, binding neurexins, neuroligins, syndecans, and the transcription factor Tbr-1, and it phosphorylates neurexin and other junctional substrates. It participates in synaptogenesis, neuronal migration, and transcriptional regulation of cortical development. Human mutations in CASK cause X-linked intellectual disability, microcephaly with pontocerebellar hypoplasia, and FG syndrome, underscoring its essential role in brain development.
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CASK Protéines Recombinantes (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
