Quilostigmine
Quilostigmine (HP-290) is an orally active Physostigmine (HY-N6608) analogue, acetylcholinesterase (IC50: 148 nM for rat brain acetylcholinesterase) inhibitor. Quilostigmine has a long-lasting effect on tremors. Quetiapine can be used in the research of Alzheimer's disease.
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- CAS No.: 139314-01-5
- Formule: C23H27N3O2
- Masse moléculaire:377.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
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AChE |
Chemical Information
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CAS No. 139314-01-5
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Masse moléculaire 377.48
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Formule C23H27N3O2
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SMILES
O=C(N1CC2=C(C=CC=C2)CC1)OC3=CC4=C(N(C)[C@]5([H])[C@@]4(C)CCN5C)C=C3
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Synonyms
HP-290; NXX-066
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Pureté et documentation
Références
[1]. Dahlin M, Björk E. Nasal administration of a physostigmine analogue (NXX-066) for Alzheimer's disease to rats. Int J Pharm. 2001 Jan 16;212(2):267-74. [Content Brief]
[2]. Snape MF, et al. A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology. 1999 Jan;38(1):181-93. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Quilostigmine Related Classifications
HY-135427 Related Classifications
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