SS28
SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 141172-08-9
- Formule: C18H20O3
- Masse moléculaire:284.35
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Tubulin[1].
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | ED50 |
9.4 μM
Compound: 6d
|
Compound was evaluated for cytotoxicity against human A-549 non-small cell lung cancer cell line.
Compound was evaluated for cytotoxicity against human A-549 non-small cell lung cancer cell line.
|
[PMID: 1613753] |
| HT-29 | ED50 |
2.3 μM
Compound: 6d
|
Cytotoxicity against human HT-29 colon cell line.
Cytotoxicity against human HT-29 colon cell line.
|
[PMID: 1613753] |
| MCF7 | ED50 |
2.4 μM
Compound: 6d
|
Cytotoxicity against human MCF-7 breast cancer cell line.
Cytotoxicity against human MCF-7 breast cancer cell line.
|
[PMID: 1613753] |
| MLM | ED50 |
6.6 μM
Compound: 6d
|
Cytotoxicity against human MLM melanoma cell line.
Cytotoxicity against human MLM melanoma cell line.
|
[PMID: 1613753] |
| SK-MEL-5 | ED50 |
8.3 μM
Compound: 6d
|
Compound was evaluated for cytotoxicity against human SKMEL-5 melanoma cell line.
Compound was evaluated for cytotoxicity against human SKMEL-5 melanoma cell line.
|
[PMID: 1613753] |
SS28 (0-20 μM) induces cytotoxicity in different cancer cell lines[1].
SS28 treatment (5 μM for A549 and 2 μM for CEM) results in cell cycle arrest at G2/M phase leading to apoptosis upon further incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:CEM, Reh, Nalm6, SUDHL8, Molt4, A549, HeLa 293T cells.
-
Concentration:1, 5, 10 and 20 μM.
-
Incubation Time:48 and 72 h.
-
Result:CEM and A549 exhibited maximum sensitivity to SS28 followed by SUDHL8, Molt4 and Reh, whereas Nalm6 showed moderate sensitivity after 48 h of the treatment. IC50 values of SS28 in CEM and A549 cell line were 2.6 and 5.2 μM, respectively, whereas in SUDHL8, Molt4, Reh and Nalm6 were 2.7, 5.1, 7.9 and 21 μ M, respectively after 48 h of treatment.
-
Cell Line:CEM and A549 cells.
-
Concentration:2 μM (CEM) and 5 μM (A549).
-
Incubation Time:6, 12, 18, 24 and 30 h.
-
Result:Showed significant accumulation of cells at G2/M phase in a time-dependent manner (6 to 24 h) and a subsequent increase in the sub-G1 population, indicative of apoptosis at 30 h in case of A549. Similarly, studies in CEM also showed a distinct G2/M arrest after 12 h of treatment, as compared to vehicle control.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c mice using EAC cells[1].
-
Dosage:15 mg/kg.
-
Administration:Orally on every alternate day for 9 doses.
-
Result:There was no further tumor progression in the mice when SS28 was administered, unlike the untreated tumor control mice.
Chemical Information
-
CAS No. 141172-08-9
-
Masse moléculaire 284.35
-
Formule C18H20O3
-
SMILES
CC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SS28 Related Classifications
HY-100761 Related Classifications
Powered by Bioz