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Cat. No.: HY-189706

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Stafori-2

Stafori-2 is a selective STAT4 SH2 domain inhibitor. Stafori-2 binds to the STAT4 Src homology 2 (SH2) domain, blocking protein-protein interactions, with a human K_i value of 0.18 μM. Stafori-2 can be used in research related to autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and type 1 diabetes.

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CAS No.: 3128949-21-0
Formule: C₁₁H₁₀FO₄PS
Masse moléculaire:288.23

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Please store the product under the recommended conditions in the Certificate of Analysis.

Stafori-2 Chemical Structure

CAS No.: 3128949-21-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

IC₅₀ & Target

^[1]

STAT4

0.18 μM (Ki)

STAT4

3.1 μM (Kd)

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In Vitro

Stafori-2 exhibits STAT4 inhibitory activity with a K_i of 0.18 μM and shows good selectivity over other STAT proteins^[1].
Stafori-2 binds to STAT4 with a K_d of 3.1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3128949-21-0
Masse moléculaire 288.23
Formule C₁₁H₁₀FO₄PS
SMILES

O=P(O)(OC1=C(F)C=C(C2=CSC(C)=C2)C=C1)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Brovchenko N, et al. Biaryl Phosphate-Based Inhibitors of the Transcription Factor STAT4. ChemMedChem. 2025 Nov 06;20(21):e202500672.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Stafori-2

Voir tous les produits spécifiques à Isoform STAT

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IC50 & Target

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