country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-107533

Copy Link Print Information

T-98475

T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC₅₀ of 0.2 nM.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 199119-18-1
Formule: C₃₇H₃₇F₂N₃O₄S
Masse moléculaire:657.77

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

T-98475 Chemical Structure

CAS No.: 199119-18-1

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC₅₀ of 0.2 nM^[1].

IC₅₀ & Target

IC₅₀: 0.2 nM (human LHRH receptor), 2 nM (monkey LHRH receptor), 4 nM (monkey anterior pituitaries), 60 nM (rat anterior pituitaries)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.2 nM Compound: 26d, T-98475	Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cells Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cells	[PMID: 16789738]
CHO	IC₅₀	0.6 nM Compound: 26d, T-98475	Inhibition of LHRH-stimulated arachidonic acid release in CHO cells expressing human LHRH receptor Inhibition of LHRH-stimulated arachidonic acid release in CHO cells expressing human LHRH receptor	[PMID: 16789738]
CHO	IC₅₀	2 nM Compound: 26d, T-98475	Inhibition of [125I]leuprorelin binding to monkey recombinant LHRH receptor expressed in CHO cells Inhibition of [125I]leuprorelin binding to monkey recombinant LHRH receptor expressed in CHO cells	[PMID: 16789738]

Chemical Information

CAS No. 199119-18-1
Masse moléculaire 657.77
Formule C₃₇H₃₇F₂N₃O₄S
SMILES

O=C(C1=CN(CC2=C(F)C=CC=C2F)C3=C(C1=O)C(CN(CC4=CC=CC=C4)C)=C(C5=CC=C(NC(C(C)C)=O)C=C5)S3)OC(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Imada T, et al. Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists. J Med Chem. 2006 Jun 29;49(13):3809-25. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis