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Tarlatamab

(Synonyms: AMG-757)
2 Cited Publications
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Based on 2 publication(s) in Google Scholar

Tarlatamab (AMG-757) is a bispecific T-cell engager (BiTE) antibody targeting delta-like ligand 3 (DLL3). DLL3 is a target that is selectively expressed in small-cell lung cancer (SCLC) tumors, but with minimal normal tissue expression. Tarlatamab has the KDs of 0.64 nM and 0.50 nM for human and nonhuman primate (NHP) DLL3, respectively. Tarlatamab has the KDs of 14.9 nM and 12 nM for human and NHP CD3, respectively. Tarlatamab is a first-in-class HLE BiTE immuno-oncology therapy targeting DLL3 and has the potential for SCLC research.

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  • Pureté: 99.77%
  • CAS No.: 2307488-83-9
  • Masse moléculaire:105.07 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tarlatamab
  • Experimental Validation Results for Tarlatamab
  • Experimental Validation Results for Tarlatamab
  • Tarlatamab Chemical Structure
    Tarlatamab Chemical Structure
CAS No.: 2307488-83-9
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[email protected] [email protected]
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  • 1/16

    (scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc

  • 1/16

    Flow cytometry analysis of Jurkat cells labelling CD3 with Tarlatamab at 142nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).

  • 1/16

    Flow cytometry analysis of DLL3 overexpression HEK293 cells labelling DLL3 with Tarlatamab at 142nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Red).

  • Tarlatamab Chemical Structure
    1/16
  • Tarlatamab
  • Flow cytometry analysis of Jurkat cells labelling CD3 with Tarlatamab at 142nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
  • Flow cytometry analysis of DLL3 overexpression HEK293 cells labelling DLL3 with Tarlatamab at 142nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Red).
  • (scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc