Tolnaftate-d7
Tolnaftate-d7 is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent.
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- CAS No.: 1329835-64-4
- Formule: C19H10D7NOS
- Masse moléculaire:314.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1329835-64-4
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Unlabeled Cas 2398-96-1
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Masse moléculaire 314.45
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Formule C19H10D7NOS
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SMILES
CN(C1=CC(C)=CC=C1)C(OC2=C([2H])C3=C(C([2H])=C([2H])C([2H])=C3[2H])C([2H])=C2[2H])=S
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Ryder, N.S., I. Frank, and M.C. Dupont, Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother, 1986. 29(5): p. 858-60. [Content Brief]
[3]. Georgopapadakou, N.H. and A. Bertasso, Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother, 1992. 36(8): p. 1779-81. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tolnaftate-d7 Related Classifications
HY-B0370S Related Classifications
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