Verruculogen
Based on 1 Customer Validation
Verruculogen is a tremorgenic mycotoxin and inhibitor of the M phase of the mammalian cell cycle. Verruculogen is produced by Penicillium and Aspergillus species. Verruculogen enhances the binding of ChTX to maxi-k channels with a K1/2 value of 170 nM. Verruculogen inhibits the amplitude of Ca2+-activated K+ currents. Verruculogen induces severe tremors in infected animals.
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- Pureté : 98.08%
- CAS No.: 12771-72-1
- Formule: C27H33N3O7
- Masse moléculaire:511.57
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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HY-17398
Mitiglinide calciumK(ATP) Channel Antagonist -
HY-N6725
SterigmatocystineDNA Synthesis Inhibitor -
HY-N6786
Ochratoxin BMycotoxin -
HY-116909
O-MethylsterigmatocystinFungal Metabolites -
HY-125699
Ochratoxin CMycotoxin -
HY-126765
Territrem BFungal Meroterpenoid -
HY-17398R
Mitiglinide calcium (Standard)K(ATP) Channel Antagonist -
HY-N6725R
Sterigmatocystine (Standard) -
HY-N6786R
Ochratoxin B (Standard)Standard of Ochratoxin B
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
20 μM
Compound: 9
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Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
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[PMID: 27865702] |
| HT-29 | IC50 |
20 μM
Compound: 9
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Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
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[PMID: 27865702] |
| Jurkat | IC50 |
20 μM
Compound: 9
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Cytotoxicity against human Jurkat cells
Cytotoxicity against human Jurkat cells
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[PMID: 27865702] |
| MCF7 | IC50 |
20 μM
Compound: 9
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Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
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[PMID: 27865702] |
In Vitro
Verruculogen enhances ChTX binding to maxi-k channels, with a K1/2 value of 170 nM[2].
Verruculogen (1 μM) significantly inhibits the amplitude of Thymol (HY-N6810)-stimulated Ca2+-activated K+ current (IK(Ca)) in pituitary GH3 cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 12771-72-1
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Appearance Solid
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Masse moléculaire 511.57
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Formule C27H33N3O7
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Color White to light brown
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SMILES
C/C(C)=C\[C@@H]1N2C3=C([C@@H]([C@@]4(N(C([C@@]5([H])N(CCC5)C4=O)=O)[C@@]3([H])CC(C)(OO1)C)O)O)C6=CC=C(OC)C=C62
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Structure Classification
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Initial Source
Penicillium verruculosum
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : ≥ 50 mg/mL (97.74 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (281 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Instruction de manipulation (2659 KB)
Références
[2]. Knaus HG, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry. 1994 May 17;33(19):5819-28. [Content Brief]
[3]. Cui CB, et al. Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures. J Antibiot (Tokyo). 1996 Jun;49(6):534-40. [Content Brief]
[4]. Huang MH, et al. Stimulatory actions of thymol, a natural product, on Ca(2+)-activated K(+) current in pituitary GH(3) cells. Planta Med. 2005 Dec;71(12):1093-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9548 mL | 9.7738 mL | 19.5477 mL | 48.8692 mL |
| 5 mM | 0.3910 mL | 1.9548 mL | 3.9095 mL | 9.7738 mL | |
| 10 mM | 0.1955 mL | 0.9774 mL | 1.9548 mL | 4.8869 mL | |
| 15 mM | 0.1303 mL | 0.6516 mL | 1.3032 mL | 3.2579 mL | |
| 20 mM | 0.0977 mL | 0.4887 mL | 0.9774 mL | 2.4435 mL | |
| 25 mM | 0.0782 mL | 0.3910 mL | 0.7819 mL | 1.9548 mL | |
| 30 mM | 0.0652 mL | 0.3258 mL | 0.6516 mL | 1.6290 mL | |
| 40 mM | 0.0489 mL | 0.2443 mL | 0.4887 mL | 1.2217 mL | |
| 50 mM | 0.0391 mL | 0.1955 mL | 0.3910 mL | 0.9774 mL | |
| 60 mM | 0.0326 mL | 0.1629 mL | 0.3258 mL | 0.8145 mL | |
| 80 mM | 0.0244 mL | 0.1222 mL | 0.2443 mL | 0.6109 mL |
Verruculogen Related Classifications
HY-N6688 Related Classifications
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