VH9
VH9 is a Free radical scavenger. VH9 binds to the active pocket of Keap1, blocks the interaction between Keap1 and Nrf2, and activates the Keap1-Nrf2 antioxidant pathway. VH9 inhibits ROS production. VH9 scavenges ABTS and DPPH free radicals through hydrogen bonding and hydrophobic interactions. VH9 protects cells from oxidative stress damage.
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- Formule: C48H63N11O17
- Masse moléculaire:1066.08
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
VH9 exhibits potent ABTS radical scavenging activity in a cell-free assay, with an IC50 of 19.698 μM[1].
VH9 exhibits DPPH radical scavenging activity in a cell-free assay, with an IC50 of 1500.825 μM[1].
VH9 (0.1-3 mg/mL; 1-2 h) exhibits good stability across varying temperatures, pH levels, NaCl concentrations, and simulated gastrointestinal digestion, retaining significant radical scavenging activity under all tested conditions[1].
VH9 (62.5-1500 μg/mL; 24 h) protects human HepG2 cells from H2O2-induced oxidative stress, increasing cell viability to up to 84.52% at a concentration of 1500 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human HepG2 cells
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Concentration:62.5-1500 μg/mL (VH9 pre-incubation); 800 μM (H2O2 incubation)
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Incubation Time:24 h (VH9 pre-incubation); 2 h (H2O2 incubation)
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Result:Significantly improved the viability of H2O2-damaged HepG2 cells, with cell viability reaching 65.67%, 80.39%, and 84.52% at concentrations of 500, 1000, and 1500 μg/mL, respectively.
Showed greater protective potency than FK10 at all tested concentrations.
Chemical Information
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Masse moléculaire 1066.08
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Formule C48H63N11O17
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Sequence
Val-Gly-Ser-Tyr-Glu-Asp-Pro-Tyr-His
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Sequence Shortening
VGSYEDPYH
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VH9 Related Classifications
HY-P11916 Related Classifications
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