Zelicapavir
Based on 1 publication(s) in Google Scholar
Zelicapavir (RSV-IN-7) (example 253) is an orally active RSV inhibitor (EC50: < 0.4 μΜ).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.10%
- CAS No.: 2070852-76-3
- Formule: C27H22F3N7O3
- Masse moléculaire:549.50
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Zelicapavir
More
Activité biologique
Description
IC50 & Target
RSV[1]
In Vitro
Zelicapavir inhibits RSV strains RSV-A Long, RSV-A2, RSV-A M37, RSV-B VR-955 in cells Hep-2, A549, Vero, HBEC, reduces the level of viral RNA in RSV-infected cells with EC50s in nanomolar levels[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hep-2, A549, Vero, HBEC
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Concentration:
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Incubation Time:6 days
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Result:Inhibited viral RNA levels.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:RSV-infected african green monkey model[2]
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Dosage:100 mg/kg
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Administration:po, twice a day for 6 days
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Result:Reduced the viral load in the bronchoalveolar lavage (BAL) fluid.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2070852-76-3
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Appearance Solid
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Masse moléculaire 549.50
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Formule C27H22F3N7O3
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Color Light yellow to yellow
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SMILES
FC(F)(C1=CC(N2CCOCC2)=C(C3=NN=C(N[C@H]4N=C(C5=CC=CC=C5)C6=CC=CC=C6NC4=O)O3)N=C1)F
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Synonyms
EDP-938; RSV-IN-7
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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mBio
A new mechanism of respiratory syncytial virus entry inhibition by small-molecule to overcome K394R-associated resistance. [Abstract]2024 Sep 11;15(9):e0138524. PMID: 39162560
Solvant et solubilité
In Vitro:
DMSO : 50 mg/mL (90.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8198 mL | 9.0992 mL | 18.1984 mL | 45.4959 mL |
| 5 mM | 0.3640 mL | 1.8198 mL | 3.6397 mL | 9.0992 mL | |
| 10 mM | 0.1820 mL | 0.9099 mL | 1.8198 mL | 4.5496 mL | |
| 15 mM | 0.1213 mL | 0.6066 mL | 1.2132 mL | 3.0331 mL | |
| 20 mM | 0.0910 mL | 0.4550 mL | 0.9099 mL | 2.2748 mL | |
| 25 mM | 0.0728 mL | 0.3640 mL | 0.7279 mL | 1.8198 mL | |
| 30 mM | 0.0607 mL | 0.3033 mL | 0.6066 mL | 1.5165 mL | |
| 40 mM | 0.0455 mL | 0.2275 mL | 0.4550 mL | 1.1374 mL | |
| 50 mM | 0.0364 mL | 0.1820 mL | 0.3640 mL | 0.9099 mL | |
| 60 mM | 0.0303 mL | 0.1517 mL | 0.3033 mL | 0.7583 mL | |
| 80 mM | 0.0227 mL | 0.1137 mL | 0.2275 mL | 0.5687 mL |
Zelicapavir Related Classifications
HY-147346 Related Classifications
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