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Cat. No.: HY-100525

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CHMFL-KIT-8140

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CAS No.: 1995876-66-8
Formule: C₃₄H₃₆F₃N₅O₅
Masse moléculaire:651.68

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (246 KB)

CHMFL-KIT-8140 Chemical Structure

CAS No.: 1995876-66-8

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Quantité

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	GI₅₀	>10 μM Compound: 35; CHMFL-KIT-8140	Cytotoxicity mouse BA/F3 cells assessed as cell growth inhibition after 72 hrs by cell titer-glo assay Cytotoxicity mouse BA/F3 cells assessed as cell growth inhibition after 72 hrs by cell titer-glo assay	[PMID: 27545040]
BaF3	GI₅₀	>10 μM Compound: 9	Growth inhibition of mouse BAF3 cells measured after 72 hrs by CCK8 assay Growth inhibition of mouse BAF3 cells measured after 72 hrs by CCK8 assay	[PMID: 31250638]
Sf9	IC₅₀	33 nM Compound: 35; CHMFL-KIT-8140	Inhibition of His-tagged cKIT (unknown origin) expressed in Sf9 cells using Poly(4:1 Glu, Tyr) peptide as substrate after 1 hr by ADP-glo kinase assay Inhibition of His-tagged cKIT (unknown origin) expressed in Sf9 cells using Poly(4:1 Glu, Tyr) peptide as substrate after 1 hr by ADP-glo kinase assay	[PMID: 27545040]
Sf9	IC₅₀	99 nM Compound: 35; CHMFL-KIT-8140	Inhibition of His-tagged cKIT T670I mutant (544 to 935 residues) (unknown origin) expressed in Sf9 cells using Poly(4:1 Glu, Tyr) peptide as substrate after 1 hr by ADP-glo kinase assay Inhibition of His-tagged cKIT T670I mutant (544 to 935 residues) (unknown origin) expressed in Sf9 cells using Poly(4:1 Glu, Tyr) peptide as substrate after 1 hr by ADP-glo kinase assay	[PMID: 27545040]

Chemical Information

CAS No. 1995876-66-8
Masse moléculaire 651.68
Formule C₃₄H₃₆F₃N₅O₅
SMILES

O=C(NC1=CC=C(N2CCC(CNC(CC)=O)CC2)C(C(F)(F)F)=C1)NC3=CC=CC(OC4=CC=NC5=CC(OC)=C(OC)C=C54)=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (246 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

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MOQ

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100 mg

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