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Cilofexor tromethamine

(Synonyms: GS-9674 tromethamine)
10 Cited Publications
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Based on 10 publication(s) in Google Scholar

Cilofexor tromethamine (GS-9674 tromethamine) is a nonsteroidal farnesene oxide receptor agonist with activity in improving markers of cholestasis and liver injury. Cilofexor tromethamine was shown to be well tolerated in patients without cirrhosis and resulted in significant improvements in liver biochemical parameters and cholestatic markers. Cilofexor tromethamine offers a potential inhibitory option for the management of primary sclerosing cholangitis.

For research use only. We do not sell to patients.

  • CAS No.: 2253764-93-9
  • Formula: C32H33Cl3N4O8
  • Molecular Weight:707.99
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Cilofexor tromethamine Chemical Structure
    Cilofexor tromethamine Chemical Structure
  • Experimental Validation Results for Cilofexor tromethamine
  • Experimental Validation Results for Cilofexor tromethamine
  • Experimental Validation Results for Cilofexor tromethamine
CAS No.: 2253764-93-9
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  • In Vivo Efficacy Study
  • Histological Imaging/Staining
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  • Cilofexor tromethamine Chemical Structure
    Cilofexor tromethamine Chemical Structure
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    Cilofexor tromethamine purchased from MedChemExpress. Usage Cited in: bioRxiv. 2024 Feb 8:2023.11.20.567833. [Abstract]

    Customer Validation
     qPCR data showing FincoR expression levels in C57BL/6 mice liver respectively treated with GW4064 (30 mg/kg), Cilofexor (30 mg/kg), Tropifexor (0.5 mg/kg), Fexaramine (100 mg/kg), or OCA (20 mg/kg) for 1 h (n=3~4/group).

  • 1/16

    Cilofexor tromethamine purchased from MedChemExpress. Usage Cited in: JHEP Rep. 2023 Sep 25;6(1):100917. [Abstract]

    Customer Validation
     Compared with the placebo group, spleen weight was reduced in the cilofexor (30 mg/kg), OCA + ASBTi, and cilofexor + ASBTi treatment groups, indicating a reduction in the inflammatory response in these groups.

  • 1/16

    Cilofexor tromethamine purchased from MedChemExpress. Usage Cited in: JHEP Rep. 2023 Sep 25;6(1):100917. [Abstract]

    Customer Validation
     Cilofexor (30 mg/kg). Liver tissues were stained with hematoxylin-eosin (H&E), Sirius Red, CK7, PDGFRβ, α-SMA, COL1A1, and desmin.

  • Cilofexor tromethamine