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Cat. No.: HY-119494

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Commendamide

Commendamide is a GPCR G2A/GPR132 agonist (EC₅₀: 11.8 μM). Commendamide can be used for research of autoimmunity and atherosclerosis.

For research use only. We do not sell to patients.

CAS No.: 193825-78-4
Formula: C₁₈H₃₅NO₄
Molecular Weight:329.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (261 KB)

Commendamide Chemical Structure

CAS No.: 193825-78-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Commendamide is a GPCR G2A/GPR132 agonist (EC₅₀: 11.8 μM). Commendamide can be used for research of autoimmunity and atherosclerosis^[1].

IC₅₀ & Target

EC50: 11.8 μM (GPR132)^[1]

Chemical Information

CAS No. 193825-78-4
Molecular Weight 329.47
Formula C₁₈H₃₅NO₄
SMILES

O=C(CNC(CC(CCCCCCCCCCCCC)O)=O)O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
- Endogenous metabolite
culture broth from the commensal bacterium Bacteroides vulgatus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cohen LJ, et al. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4825-34. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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