Corifollitropin alfa
Based on 1 Customer Validation
Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC50 of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility.
For research use only. We do not sell to patients.
- CAS No.: 195962-23-3
- Molecular Weight:25.4 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
FSH Receptor[2]
Corifollitropin alfa (2.5-40 μg/kg, s.c.) stimulates superovulation in rats[2].
Corifollitropin alfa (3 μg, supplemented with hCG, s.c.) increases ovulation rate and recovered embryos in rabbits[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[2]
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Dosage:2.5, 5, 10, 20, 40 μg/kg.
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Administration:Subcutaneous injection (s.c), four injections given on 2 subsequent days (0, 8, 24, and 32 h).
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Result:Increased the number of ovulated oocytes, reached maximal value at 20 μg/kg.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Fusion-Follicle-stimulating hormone (FSH)-CTP (C-terminal peptide of the β-subunit of human chorionic gonadotropin (hCG))
Chemical Information
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CAS No. 195962-23-3
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Appearance Liquid
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Molecular Weight 25.4 kDa
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Color Colorless to light yellow
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SMILES
[Corifollitropin alfa]
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Synonyms
Org 36286; MK-8962
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Loutradis D, et al. Corifollitropin alfa, a long-acting follicle-stimulating hormone agonist for the treatment of infertility. Curr Opin Investig Drugs. 2009 Apr;10(4):372-80. [Content Brief]
[2]. Verbost P, et al. Pharmacologic profiling of corifollitropin alfa, the first developed sustained follicle stimulant. Eur J Pharmacol. 2011 Jan 25;651(1-3):227-33. [Content Brief]
[3]. Viudes-de-Castro MP, et a. A single injection of corifollitropin alfa supplemented with human chorionic gonadotropin increases follicular recruitment and transferable embryos in the rabbit. Reprod Domest Anim. 2019 Apr;54(4):696-701. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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