Corifollitropin alfa (Synonyms: Org 36286; MK-8962)

Cat. No.: HY-118860: FAQs
Data Sheet

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Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC₅₀ of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility.

For research use only. We do not sell to patients.

Corifollitropin alfa Chemical Structure

CAS No. : 195962-23-3

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1 mg		Get quote	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

FSH Receptor^[2]

In Vivo

Corifollitropin alfa (20 μg/kg, s.c., single injection) shows a t_1/2 of 17.3 h and C_max of 3.2 ng/mL/μg/kg in female Wistar rats^[2].
Corifollitropin alfa (2.5-40 μg/kg, s.c.) stimulates superovulation in rats^[2].
Corifollitropin alfa (3 µg, supplemented with hCG, s.c.) increases ovulation rate and recovered embryos in rabbits^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats^[2]
Dosage:	2.5, 5, 10, 20, 40 μg/kg.
Administration:	Subcutaneous injection (s.c), four injections given on 2 subsequent days (0, 8, 24, and 32 h).
Result:	Increased the number of ovulated oocytes, reached maximal value at 20 μg/kg.

Clinical Trial

CAS No.

195962-23-3

SMILES

[Corifollitropin alfa]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Loutradis D, et al. Corifollitropin alfa, a long-acting follicle-stimulating hormone agonist for the treatment of infertility. Curr Opin Investig Drugs. 2009 Apr;10(4):372-80. [Content Brief]

[2]. Verbost P, et al. Pharmacologic profiling of corifollitropin alfa, the first developed sustained follicle stimulant. Eur J Pharmacol. 2011 Jan 25;651(1-3):227-33. [Content Brief]

[3]. Viudes-de-Castro MP, et a. A single injection of corifollitropin alfa supplemented with human chorionic gonadotropin increases follicular recruitment and transferable embryos in the rabbit. Reprod Domest Anim. 2019 Apr;54(4):696-701. [Content Brief]

Corifollitropin alfa Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Corifollitropin alfa195962-23-3Org 36286 MK-8962Org36286Org-36286MK8962MK 8962MK-8962Estrogen Receptor/ERRLong-actingFSHovulationinfertilityInhibitorinhibitorinhibit

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