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  3. Corifollitropin alfa

Corifollitropin alfa  (Synonyms: Org 36286; MK-8962)

Cat. No.: HY-118860

Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC50 of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility.

For research use only. We do not sell to patients.

Corifollitropin alfa Chemical Structure

Corifollitropin alfa Chemical Structure

CAS No. : 195962-23-3

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Description

Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC50 of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility[1][2][3].

IC50 & Target

FSH Receptor[2]

In Vivo

Corifollitropin alfa (20 μg/kg, s.c., single injection) shows a t1/2 of 17.3 h and Cmax of 3.2 ng/mL/μg/kg in female Wistar rats[2].
Corifollitropin alfa (2.5-40 μg/kg, s.c.) stimulates superovulation in rats[2].
Corifollitropin alfa (3 µg, supplemented with hCG, s.c.) increases ovulation rate and recovered embryos in rabbits[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[2]
Dosage: 2.5, 5, 10, 20, 40 μg/kg.
Administration: Subcutaneous injection (s.c), four injections given on 2 subsequent days (0, 8, 24, and 32 h).
Result: Increased the number of ovulated oocytes, reached maximal value at 20 μg/kg.
CAS No.
SMILES

[Corifollitropin alfa]

Storage

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Corifollitropin alfa
Cat. No.:
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