Cys-Gly-3M3SH
Cys-Gly-3M3SH is an odorless thiol precursor dipeptide and the major secreted precursor of the human axillary odorant 3M3SH, which forms thiol body odor after biotransformation by the skin microbiota. Cys-Gly-3M3SH is biotransformed into 3M3SH by certain staphylococci. Cys-Gly-3M3SH is actively taken up by bacteria via a secondary transport system dependent on the proton motive force. Cys-Gly-3M3SH is used in research related to osmidrosis and skin diseases.
For research use only. We do not sell to patients.
- CAS No.: 872188-59-5
- Formula: C12H24N2O4S
- Molecular Weight:292.39
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
Description
In Vitro
Cys-Gly-3M3SH (2 h) releases 3M3SH from axillary secretions under the combined action of TpdA and C-S lyase, confirming that this novel dipeptidase is involved in the release of odor compounds[1].
Cys-Gly-3M3SH (0.5-1 mM; 5 min) is hydrolyzed by purified recombinant TpdA with a Km of 0.045 mM and a Vmax of 0.023 mmol/min/mg, indicating its high affinity for the physiological substrate[1].
Cys-Gly-3M3SH (2 mM; 24 h) is efficiently biotransformed by Staphylococcus hominis, Staphylococcus haemolyticus, and Staphylococcus lugdunensis, whereas Staphylococcus epidermidis, the most abundant commensal in the axilla, and most corynebacteria display negligible biotransformation activity[2].
Cys-Gly-3M3SH biotransformation by Staphylococcus hominis and Staphylococcus haemolyticus G431 is inhibited by CCCP (HY-100941) and Sodium Orthovanadate (HY-D0852), indicating that active transport of Cys-Gly-3M3SH is required for 3M3SH production[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 872188-59-5
-
Molecular Weight 292.39
-
Formula C12H24N2O4S
-
SMILES
C(SC[C@@H](C(NCC(O)=O)=O)N)(CCC)(CCO)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Research Protocol for Microbiome Analysis
Microbiome analysis characterizes microbial communities in biological or environmental samples by measuring community composition, diversity, taxonomic structure, functional potential, and associations with host or environmental phenotypes. 16S rRNA gene amplicon sequencing is commonly used for bacterial and archaeal taxonomic profiling, while shotgun metagenomics provides higher taxonomic resolution and direct functional information, including microbial genes, pathways, viruses, fungi, and antimicrobial-resistance genes when sequencing depth and host-DNA contamination are adequately controlled. Microbiome results are strongly affected by sample collection, storage, DNA extraction, contamination, sequencing method, reference database, and bioinformatic pipeline; therefore, standardized protocols, negative controls, mock communities, and transparent analysis workflows are required. Unresolved issues include low-biomass contamination, compositional-data bias, inconsistent species-level c
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cys-Gly-3M3SH Related Classifications
HY-156006 Related Classifications
Powered by Bioz