DC41SMe
DC41SMe, a DC1 derivative, shows cytotoxicity in Ramos, Namalwa, and HL60/s cells with IC50s ranging from 18-25 pM. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer.
For research use only. We do not sell to patients.
- CAS No.: 1354787-71-5
- Formula: C38H36ClN5O4S2
- Molecular Weight:726.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Duocarmycins |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | IC50 |
220 pM
Compound: 26, DC41SMe
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Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay
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[PMID: 22148292] |
| HL-60 | IC50 |
25 pM
Compound: 26, DC41SMe
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Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay
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[PMID: 22148292] |
| NAMALVA | IC50 |
21 pM
Compound: 26, DC41SMe
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Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay
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[PMID: 22148292] |
| Ramos | IC50 |
18 pM
Compound: 26, DC41SMe
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Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay
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[PMID: 22148292] |
Chemical Information
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CAS No. 1354787-71-5
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Molecular Weight 726.31
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Formula C38H36ClN5O4S2
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SMILES
O=C(C(N1)=CC2=C1C=CC(NC(CCC(SSC)(C)C)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. [Content Brief]
[2]. Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DC41SMe Related Classifications
HY-112900 Related Classifications
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