DCN1-IN-3
DCN1-IN-3 is a DCN1 inhibitor with a Kd of 0.311 μM. DCN1-IN-3 inhibits Cullin neddylation. DCN1-IN-3 can be used for research on lung cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C25H35N3O3S
- Masse moléculaire:457.63
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCC95 | EC50 |
13 μM
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Antiproliferative activity against human HCC95 lung cancer cells assessed as viability reduction.
Antiproliferative activity against human HCC95 lung cancer cells assessed as viability reduction.
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5453876 |
| BJ | EC50 |
>30 μM
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Antiproliferative activity against immortalized BJ fibroblast cells assessed as viability reduction with EC50 greater than 30 μM.
Antiproliferative activity against immortalized BJ fibroblast cells assessed as viability reduction with EC50 greater than 30 μM.
|
5453876 |
In Vitro
DCN1-IN-3 binds to DCN1 by ITC with a Kd of 0.311 µM[1].
DCN1-IN-3 inhibits DCN1-mediated CUL2 neddylation in vitro with an IC50 of 2.2 µM[1].
DCN1-IN-3 shows low hERG binding, with Ki >30 µM[1].
DCN1-IN-3 (3-30 µM) inhibits HCC95 colony formation in soft agar[1].
DCN1-IN-3 (10 µM) stabilizes DCN1 in HCC95 cells at 53.5 °C[1].
DCN1-IN-3 (10-20 µM; 16 h) inhibits CUL3 neddylation in HCC95 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCC95 cells
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Concentration:10 and 20 µM
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Incubation Time:16 h
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Result:Greater inhibition of CUL3 neddylation was observed at 20 µM than with NAcM-OPT; inhibition at 10 µM was comparable.
Chemical Information
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Masse moléculaire 457.63
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Formule C25H35N3O3S
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SMILES
O=C(N(C1CCN(S(C(C)CCC)(=O)=O)CC1)CC2CCC2)C(N=C3)=CC4=C3C=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DCN1-IN-3 Related Classifications
HY-191436 Related Classifications
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