1. PROTAC
  2. PROTAC Linkers
  3. Dde Biotin-PEG4-alkyne

Dde Biotin-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Dde Biotin-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Dde Biotin-PEG4-alkyne Chemical Structure

Dde Biotin-PEG4-alkyne Chemical Structure

CAS No. : 1802908-00-4

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5 mg USD 180 In-stock
10 mg USD 290 In-stock
25 mg USD 540 In-stock
50 mg USD 860 In-stock
100 mg USD 1380 In-stock
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Description

Dde Biotin-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Dde Biotin-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

650.83

Formula

C32H50N4O8S

CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C(NCCOCCOCCOCCOCC/C(NCC#C)=C1C(CC(C)(C)CC\1=O)=O)CCCC[C@H]2SC[C@@]([C@@]2([H])N3)([H])NC3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Dde Biotin-PEG4-alkyne Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Dde Biotin-PEG4-alkyne
Cat. No.:
HY-140924
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