Art. -Nr.: HY-12403

Talfirastide

(Synonyms: TXA127; Angiotensin (1-7); Ang-(1-7))

17 Cited Publications

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Based on 17 publication(s) in Google Scholar

Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .

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Reinheit: 99.90%
CAS. Nr.: 51833-78-4
Formel: C₄₁H₆₂N₁₂O₁₁
Molecular Weight:899.00

Speicherung:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Talfirastide Chemical Structure

CAS. Nr.: 51833-78-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (17)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

AT1 Receptor

Alle Angiotensin Receptor Isoform-spezifische Produkte anzeigen :

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Angiotensin 1-7 (Ang-(1-7)) inhibits cultured vascular smooth muscle cell growth, whereas equal molar concentration of Ang II stimulates cell growth^[2].
Angiotensin 1-7 (Ang 1-7) abrogates the methylglyoxal-modified albumin (MGA)-stimulated myofibroblast phenotype by inhibiting the chronic stimulation of the TGF-β-ERK pathway in NRK-52E cells^[4].
Angiotensin 1-7 signals through the Mas receptor ( MasR) in opposition to Ang II/angiotensin II type 1 receptor (AT1R), promoting anti-inflammatory,vasodilatory, and neuroprotective effects^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Daily Angiotensin 1-7 (Ang-(1-7)) treatment (0.01-0.06 mg/kg) results in significant amelioration of DSS-induced colitis. Colitis-associated phosphorylation of p38, ERK1/2 and Akt is reduced by Ang 1-7 treatment^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 51833-78-4
Appearance Solid
Molecular Weight 899.00
Formel C₄₁H₆₂N₁₂O₁₁
Color White to off-white
Synonyms

TXA127; Angiotensin (1-7); Ang-(1-7)
Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro
Sequence Shortening

DRVYIHP
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (17)

All Cell Imaging/StainingWBFlow CytometryRT-PCRIn Vivo Efficacy StudyIHC

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Journal Impact Factor

Proc Natl Acad Sci U S A

Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis. [Abstract]

2025 Dec 9;122(49):e2515641122. PMID: 41348733
Chin Chem Lett

Nanokit coupled electrospray ionization mass spectrometry for analysis of angiotensin converting enzyme 2 activity in single living cell. [Abstract]

2023 Mar;34(3):107522. PMID: 35602918
Phytomedicine

Baicalin and ginsenoside Rb1 suppress the activation of cardiac fibroblasts via regulating the GRK2/AT1R/MasR network. [Abstract]

2025 Oct 4:148:157371. PMID: 41110355
Cell Biosci

Ang-(1-7)/MasR axis promotes functional recovery after spinal cord injury by regulating microglia/macrophage polarization. [Abstract]

2023 Feb 4;13(1):23. PMID: 36739421

Talfirastide purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23. [Abstract]

Ang-(1–7) (Talfirastide, 10⁻⁶ mol/L, 24 h) regulates the polarization of macrophages towards the M2 phenotype. Double-staining for F4/80 (green)/iNOS (red) or F4/80 (green)/Arg-1 (red) in each group of macrophages (scale bar: 50 μm, n = 5).

Talfirastide purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23. [Abstract]

(Talfirastide, 10⁻⁶ mol/L). Representative immunoblots and quantification of macrophages in each group showing the expression of iNOS and Arg-1 after treatment for 24 h (n = 3).

Talfirastide purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23. [Abstract]

Talfirastide (10⁻⁶ mol/L, 24h). The ratio of M1 macrophage phenotype-related surface markers, CD86/CD11b, were determined by flow cytometry for each group (n = 3).

Talfirastide purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23. [Abstract]

Talfirastide (10⁻⁶ mol/L, 24h). The ratio of M2 macrophage phenotype-related surface markers, CD206/ CD11b, were determined by flow cytometry for each group (n = 3).

Talfirastide purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23. [Abstract]

Ang-(1–7) (Talfirastide, 10⁻⁶ mol/L, 24h) inhibits inflammation response by modulating the expression of inflammatory cytokines in BMDMs. Quantitative RT-qPCR analysis of macrophages showing mRNA expression of IL-1β, TNF-α, IL-10, IL-4 after treatment for 24 h. GAPDH: loading control. Data are expressed as fold change compared to the control group (n = 3).

Talfirastide purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23. [Abstract]

Ang-(1–7)(Talfirastide, 10⁻⁶ mol/L, 24h) inhibits inflammation response by modulating the expression of inflammatory cytokines. Representative immunoblots and quantification showing protein expression of IL-1β and TNF-α in the macrophages after treatment for 24 h.

Talfirastide purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23. [Abstract]

Ang-(1–7) (Talfirastide; administered immediately by intrathecal injection; 10 μL; 500 ng) improved the motor function of rats after SCI. a Basso, Beattie and Bresnahan (BBB) scores (n = 6) and Inclined plane test scores (n = 6).

Talfirastide purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Feb 4;13(1):23. [Abstract]

Continuous sections of the spinal cord by HE staining were obtained on the 28th day post-surgery, and the remaining neurons in the SCI group, SCI + Ang-(1–7) groups, and SCI + Ang-(1–7) + A779 groups at the same distance from the epicenter were displayed. (scale bar: 100 μm and 40 μm, n = 3).
Acta Physiol

Angiotensin-(1-7) Alleviates Isoproterenol-Induced Cardiac Hypertrophy by Suppressing Autophagy and Apoptosis Through the Synergistic Action of Mas Receptor and Angiotensin II Type 2 Receptor. [Abstract]

2026 Apr;242(4):e70200. PMID: 41886752
Chem Biol Interact

Mechanism of ferroptosis in hypoxia-induced pulmonary vascular remodeling in hypoxia pulmonary hypertension: a study based on the ACE2-Ang-(1-7)-Mas axis. [Abstract]

2025 Jun 2:111596. PMID: 40466901
Biol Proced Online

Angiotensin-converting enzyme 2 identifies immuno-hot tumors suggesting angiotensin-(1-7) as a sensitizer for chemotherapy and immunotherapy in breast cancer. [Abstract]

2022 Oct 25;24(1):15. PMID: 36284262
Front Cell Dev Biol

SARS-CoV-2 Host Receptor ACE2 Protein Expression Atlas in Human Gastrointestinal Tract. [Abstract]

2021 Jun 11:9:659809. PMID: 34178985
J Inflamm Res

Angiotensin-(1-7) Modulates the Warburg Effect to Alleviate Inflammation in LPS-Induced Macrophages and Septic Mice. [Abstract]

2024 Jan 24:17:469-485. PMID: 38282712
Sci Rep

Ginsenoside Rg1 alleviates HG-induced autophagy of retinal microvascular endothelial cells by activating ACE2/Ang1-7/Mas in vitro. [Abstract]

2025 Nov 25. PMID: 41290961
Front Biosci (Landmark Ed)

ACE2 Alleviates Endoplasmic Reticulum Stress and Protects against Pyroptosis by Regulating Ang1-7/Mas in Ventilator-Induced Lung Injury. [Abstract]

2024 Sep 24;29(9):334. PMID: 39344337
BMC Pulm Med

Angiotensin-(1-7) suppresses airway inflammation and airway remodeling via inhibiting ATG5 in allergic asthma. [Abstract]

2023 Nov 2;23(1):422. PMID: 37919667
Endokrynol Pol

Angiotensin (1-7) reverses glucose-induced islet β cell dedifferentiation by Wnt/β-catenin/FoxO1 signalling pathway. [Abstract]

2023;74(5):544-552. PMID: 37779373
Int J Clin Exp Med

2019;12(5):4773-4780.
bioRxiv

2026 Mar 25.
SSRN

2025 Feb 28.
Research Square Preprint

2024 Feb 19.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 25 mg/mL (27.81 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1123 mL

5.5617 mL

11.1235 mL

5 mM

0.2225 mL

1.1123 mL

2.2247 mL

10 mM

0.1112 mL

0.5562 mL

1.1123 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (111.23 mM); Clear solution; Need ultrasonic

Protokoll

Kinase Assay^[1]

Competition assays using purified canine ACE are determined using a fixed concentration of the substrate Hip-His-Leu (1 mM) and varying the concentrations of the competing agents [Lisinopril (0.1 to 100 nM), Angiotensin (1-7) (10 nM to 10 μM), or Sar¹, Thr⁸-Ang II (10 nM to 10 μM)]. Inhibitory constants (IC₅₀) are determined from the respective competition curves. To study the effect of Angiotensin (1-7) on BK metabolism in intact coronary rings, ¹²⁵I-[Tyr⁰]-BK (final concentration of 1 nM) is added to the tubes containing three rings preincubated with 1 mL Krebs' buffer and aerated with 95% O₂ and 5% CO₂ at 37°C. Lisinopril (2 μM), Angiotensin (1-7) (2 μM), or Krebs' buffer as control are added to the rings 10 minutes before addition of the radiolabeled BK. Aliquots of the incubation medium are removed at 5, 10, and 20 minutes and diluted with 1% HFBA to inhibit peptidase activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Assay^[2]

500 μM Methylglyoxal is incubated with 100 μM BSA dissolved in phosphate buffered saline (PBS) for 24 hours, then washed on 10 kDa filters to remove excess methyl glyoxal, reconstituted with DMEM/F12 serum free media and passed through a 0.2 μmicron filter. TGF-β (5 ng/mL) is prepared to treat cells in a subset of experiments. Cells are co-treated with one or combinations of the following: Angiotensin (1-7) (100 nM), D-Ala7-Ang-(1-7) (10 μM), ERK1/2 kinase inhibitor, PD 98059 (1 μM), TGF-β receptor kinase inhibitor; SB525334 (1 μM), the AT₁ receptor antagonist Losartan (1 μM), the renin inhibitor Aliskerin (1 μM) and the ACE inhibitor Lisinopril (1 μM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[3]^[4]

Mice^[3]
Male and female BALB/c mice (1:1 ratio, 6-10 weeks old, mean weight 20 g.) are used. Angiotensin fragment 1-7 acetate salt hydrate (Ang 1-7) is dissolved in 0.9% saline (vehicle) at 1 mg/mL and stored at -80°C. Various doses (0.01, 0.06, 0.1, 0.3 and 1 mg/kg) are freshly prepared from the stock each day of the experiment, and administered to mice by daily intra-peritoneal (i.p) injections in a volume of 500 μL per injection, either before (prophylactic approach) or after (treatment approach) DSS treatment. A779 (MAS-1 R antagonist) is similarly dissolved in distilled water at 1 mg/mL and stored at -80°C. A freshly prepared dose of 1 mg/kg is administered to a second group of mice by daily i.p injections in a volume of 500 μL daily (for 4 days) along with colitis induction (prophylactic approach). A third group of mice receive DSS containing water and daily i.p injections of 0.9% saline (vehicle). The fourth group receive DSS containing water along with daily i.p injections with Dexamethasone (DEX) at doses of 0.01-1.0 mg/kg or its vehicle (0.9% saline) (prophylactic approach).
Rats^[4]
Twenty six ovariectomized female Wistar rats weighing 200±20 g are used. Angiotensin (1-7) is administered intravenously by a microsyringe pump at two different continuous doses of 100 and 300 ng/kg/min after antagonist/saline infusion. Each dose is infused for 15 min; and MAP, RPP, and RBF are recorded during Angiotensin (1-7) infusion and the last 3-5 min of each dose measured as “response to Angiotensin (1-7) infusion”. During Angiotensin (1-7) infusion, RPP is sustained at pre-Ang1-7 infusion levels via an adjustable aortic clamp.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (291 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gómez-Mendoza DP, et al. Angiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4. J Proteomics. 2019;208:103486. [Content Brief]

[2]. Li P, et al. Angiotensin-(1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide. Hypertension. 1997 Jan;29(1 Pt 2):394-400. [Content Brief]

[3]. Khajah MA, et al. Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis. PLoS One. 2016 Mar 10;11(3):e0150861. [Content Brief]

[4]. Alzayadneh EM, et al. Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Cell Signal. 2014 Sep 19. pii: S0898-6568(14)00314-3. [Content Brief]

[5]. Janatpour ZC, et al. Subcutaneous Administration of Angiotensin-(1-7) Improves Recovery after Traumatic Brain Injury in Mice. J Neurotrauma. 2019;36(22):3115-3131. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.1123 mL	5.5617 mL	11.1235 mL	27.8087 mL
	5 mM	0.2225 mL	1.1123 mL	2.2247 mL	5.5617 mL
	10 mM	0.1112 mL	0.5562 mL	1.1123 mL	2.7809 mL
	15 mM	0.0742 mL	0.3708 mL	0.7416 mL	1.8539 mL
	20 mM	0.0556 mL	0.2781 mL	0.5562 mL	1.3904 mL
	25 mM	0.0445 mL	0.2225 mL	0.4449 mL	1.1123 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Talfirastide

17 Cited Publications

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Talfirastide

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Publications Citing Use of MedChemExpress (MCE) Talfirastide

Alle Angiotensin Receptor Isoform-spezifische Produkte anzeigen

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (17)

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Talfirastide Related Classifications

HY-12403 Related Classifications