Acetylcholine-d4 bromide
Based on 1 Customer Validation
Acetylcholine-d4 (ACh-d4) bromide is the deuterated-labeled Acetylcholine bromide (HY-B0282A). Acetylcholine (ACh) bromide, a neurotransmitter, is a potent cholinergic agonist. Acetylcholine bromide is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs). Acetylcholine bromide inhibits p53 mutant peptide aggregation in vitro.
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- Reinheit : 98.0%
- CAS. Nr.: 93449-31-1
- Formel: C7H12D4BrNO2
- Molecular Weight:230.14
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 93449-31-1
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Unlabeled CAS 66-23-9
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Appearance Solid
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Molecular Weight 230.14
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Formel C7H12D4BrNO2
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Color White to off-white
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SMILES
[2H]C([2H])(OC(C)=O)C([N+](C)(C)C)([2H])[2H].[Br-]
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Synonyms
ACh-d4 bromide
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 250 mg/mL (1086.30 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (288 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[2]. A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31(2):162-9. [Content Brief]
[3]. Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300(7):335-41. [Content Brief]
[4]. P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150(3):340-2. [Content Brief]
[5]. Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24(4):353-357. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.3452 mL | 21.7259 mL | 43.4518 mL | 108.6295 mL |
| 5 mM | 0.8690 mL | 4.3452 mL | 8.6904 mL | 21.7259 mL | |
| 10 mM | 0.4345 mL | 2.1726 mL | 4.3452 mL | 10.8630 mL | |
| 15 mM | 0.2897 mL | 1.4484 mL | 2.8968 mL | 7.2420 mL | |
| 20 mM | 0.2173 mL | 1.0863 mL | 2.1726 mL | 5.4315 mL | |
| 25 mM | 0.1738 mL | 0.8690 mL | 1.7381 mL | 4.3452 mL | |
| 30 mM | 0.1448 mL | 0.7242 mL | 1.4484 mL | 3.6210 mL | |
| 40 mM | 0.1086 mL | 0.5431 mL | 1.0863 mL | 2.7157 mL | |
| 50 mM | 0.0869 mL | 0.4345 mL | 0.8690 mL | 2.1726 mL | |
| 60 mM | 0.0724 mL | 0.3621 mL | 0.7242 mL | 1.8105 mL | |
| 80 mM | 0.0543 mL | 0.2716 mL | 0.5431 mL | 1.3579 mL | |
| 100 mM | 0.0435 mL | 0.2173 mL | 0.4345 mL | 1.0863 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Acetylcholine-d4 bromide Related Classifications
HY-B0282AS1 Related Classifications
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