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Art. -Nr.: HY-174343

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ELQ-121

ELQ-121 is a potent inhibitor of the ubiquinol-oxidation (Q_O)-site of parasites. ELQ-121 has IC₅₀ of 0.05 nM against chloroquine sensitive and multidrug resistant P. falciparum in vitro. ELQ-121 inhibits T. gondii and N. caninum with IC₅₀ below 1 nM in vitro. ELQ-121 suppresses B. besnoiti tachyzoite proliferation with an IC₅₀ of 0.49 nM and induces mitochondrial disruption. ELQ-121 can form polyethylene glycol carbonate ester prodrug which demonstrates in vivo efficacy against P. yoelii in mice. ELQ-121 is suitable for antimalarial research.

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CAS. Nr.: 1228283-36-0
Formel: C₁₇H₂₁F₂NO
Molecular Weight:293.35

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

ELQ-121 Chemical Structure

CAS. Nr.: 1228283-36-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Chemical Information

CAS. Nr. 1228283-36-0
Molecular Weight 293.35
Formel C₁₇H₂₁F₂NO
SMILES

FC1=C2C(NC(C)=C(CCCCCCC)C2=O)=CC(F)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Probst, A. S., et al., (2025). In vivo screen of Plasmodium targets for mosquito-based malaria control. Nature. Advance online publication. [Content Brief]

[2]. Eberhard, N., et al., (2020). Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites. Frontiers in veterinary science, 7, 96. [Content Brief]

[3]. Winter, R., et al., (2011). Optimization of endochin-like quinolones for antimalarial activity. Experimental parasitology, 127(2), 545–551. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ELQ-121

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

Chemical Information

Reinheit & Dokumentation

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Calculators

Help & FAQs

ELQ-121 Related Classifications

HY-174343 Related Classifications

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