DAPK1 - death associated protein kinase 1 Gene

Also Known as DAPK; ROCO3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1612

About DAPK1

Cytogenetic location: 9q21.33 Genomic coordinates (GRCh38): 9:87,497,228-87,708,634 (from NCBI)

This gene has 19 transcripts (splice variants), 211 orthologues and 4 paralogues. Ubiquitous expression in lung (RPKM 19.2), ovary (RPKM 16.6) and 25 other tissues.

Summary

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD Calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

DAPK1 Products (4)

mRNA	Protein	Name
NM_001288729.2	NP_001275658.1	death-associated protein kinase 1
NM_001288730.2	NP_001275659.1	death-associated protein kinase 1
NM_001288731.2	NP_001275660.1	death-associated protein kinase 1
NM_004938.4	NP_004929.2	death-associated protein kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10629061	GOA
enables calcium/calmodulin-dependent protein kinase activity	IDA IDA: Inferred from direct assay	10629061	GOA
enables calmodulin binding	IDA IDA: Inferred from direct assay	10629061	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19180116	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15616583	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	7828849	GOA
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	12730201	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within apoptotic process	IGI IGI: Inferred from genetic interaction	7828849	GOA
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	10629061	GOA
involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	7828849	GOA
involved in cellular response to hydroperoxide	IMP IMP: Inferred from mutant phenotype	22095288	GOA
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	18995835	GOA
involved in defense response to tumor cell	IMP IMP: Inferred from mutant phenotype	30429596	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10629061	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	18995835	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10629061	GOA
involved in positive regulation of autophagic cell death	IMP IMP: Inferred from mutant phenotype	11980920	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	22095288	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16132846	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10629061	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10629061	GOA
involved in regulation of response to tumor cell	IDA IDA: Inferred from direct assay	11573098	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of DAPK1-calmodulin complex	IPI IPI: Inferred from physical interaction	20103772	GOA
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	10629061	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12730201	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12730201	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAPK1 Protein Structure

Pkinase

Ank_4

Ank_2

Ank

Ank_2

Death

0
300
600
900
1200
1430 a.a.

Protein Preferred Names	Protein Names
death-associated protein kinase 1	DAP kinase 1

DAPK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	DAPK1	P53355	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	20220139
Intra	DAPK1	P53355	PPP2R2A	Homo sapiens	P63151	RNAi	20220139
Intra	DAPK1	P53355	PPP2R2A	Homo sapiens	P63151	Pull Down	32707033
Intra	DAPK1	P53355	LRRK1	Homo sapiens	Q38SD2	Anti Tag CoIP	19712061
Intra	DAPK1	P53355	LIMA1	Homo sapiens	Q9UHB6	Pull Down	32707033
Intra	DAPK1	P53355	PDCD6	Homo sapiens	O75340	Anti Tag CoIP	16132846
Intra	DAPK1	P53355	PDCD6	Homo sapiens	O75340	Y2H	16132846
Intra	DAPK1	P53355	PKM	Homo sapiens	P14618	Anti Tag CoIP	21725354
Intra	DAPK1	P53355	BAG2	Homo sapiens	O95816	Anti Tag CoIP	25852190
Intra	DAPK1	P53355	STUB1	Homo sapiens	Q9UNE7	Pull Down	32707033
Intra	DAPK1	P53355	IFI30	Homo sapiens	P13284	Pull Down	32707033
Intra	DAPK1	P53355	DAPK1	Homo sapiens	P53355	Protein Kinase Assay	19180116
Intra	DAPK1	P53355	KLHL20	Homo sapiens	Q9Y2M5	Anti Bait CoIP	20389280
Intra	DAPK1	P53355	DAPK1	Homo sapiens	P53355	GMS	19712061
Intra	DAPK1	P53355	DAPK1	Homo sapiens	P53355	Anti Tag CoIP	19712061
Intra	DAPK1	P53355	DAPK1	Homo sapiens	P53355	GMS	21738225
Intra	DAPK1	P53355	DAPK1	Homo sapiens	P53355	Anti Tag CoIP	21738225
Intra	DAPK1	P53355	IFI30	Homo sapiens	P13284	Anti Tag CoIP	25852190
Intra	DAPK1	P53355	KLHL20	Homo sapiens	Q9Y2M5	Anti Tag CoIP	20389280
Intra	DAPK1	P53355	KLHL20	Homo sapiens	Q9Y2M5	Competition Binding	20389280
Intra	DAPK1	P53355	KLHL20	Homo sapiens	Q9Y2M5	Y2H	20389280
Intra	DAPK1	P53355	PKM	Homo sapiens	P14618-1	Y2H	21725354
Intra	DAPK1	P53355	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	19712061
Intra	DAPK1	P53355	MAPK3	Homo sapiens	P27361	Y2H	15616583
Intra	DAPK1	P53355	MAPK3	Homo sapiens	P27361	Pull Down	15616583
Intra	DAPK1	P53355	BECN1	Homo sapiens	Q14457	Protein Kinase Assay	19180116

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DAPK1 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P76858	DAPK1 Protein, Human (Active, sf9, His-GST)	P53355-1 (M1-L363)	≥ 80%, as determined by reducing SDS-PAGE.

DAPK1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83053	DAP Kinase 1 Antibody (YA2798)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pancreatic Ductal Adenocarcinoma	Ductal Adenocarcinoma Of The Pancreas
Cervical Squamous Cell Carcinoma	Squamous Cell Carcinoma Of The Cervix Uteri Squamous Cell Carcinoma Of Cervix
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Ischemia	Acute Coronary Syndrome
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Cholecystitis	Acute Cholecystitis Chronic Cholecystitis Acalculous Cholecystitis Acute And Chronic Cholecystitis Acute On Chronic Cholecystitis Gallstone Cholecystitis Cholecystitis, Acute Calculus Of Gallbladder With Cholecystitis Gallbladder Inflammation Acute Cholecystitis Infection Acute Acalculous Cholecystitis Chronic Acalculous Cholecystitis Nonfunctioning Gallbladder
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Primary Central Nervous System Lymphoma	Pcnsl Primary Cns Lymphoma Primary Brain Lymphoma Primary Lymphoma, Cns Primary Cerebral Lymphoma
Mixed Oligodendroglioma-Astrocytoma	Who Grade Ii Mixed Glioma
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-123581	Quinocetone	Activator	98.25%	Unkown
HY-179055	PROTAC DAPK1 Degrader-1	Degrader	96.70%	Unkown
HY-175477	UNC9750	Inhibitor	/	Unkown
HY-125404	DAPK-IN-1	Inhibitor	/	Unkown
HY-178967	DRAK1/2-IN-2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DAPK1	RGD	RGD:1311629
Bos taurus	DAPK1	VGNC	VGNC:27877
Macaca mulatta	DAPK1	VGNC	VGNC:71732
Canis familiaris	DAPK1	VGNC	VGNC:39770
Mus musculus	DAPK1	MGD	MGI:1916885
Felis catus	DAPK1	VGNC	VGNC:61337
Others	DAPK1	NCBI