FOXJ2 - forkhead box J2 Gene

Also Known as FHX

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55810

About FOXJ2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,032,716-8,055,517 (from NCBI)

This gene has 3 transcripts (splice variants), 124 orthologues and 42 paralogues. Ubiquitous expression in endometrium (RPKM 8.4), ovary (RPKM 8.2) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FOXJ2 Products (1)

mRNA Protein Name
NM_018416.3 NP_060886.1 forkhead box protein J2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10777590 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10777590 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25609649 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10777590 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
24792364 GOA
involved in negative regulation of blood vessel endothelial cell differentiation IDA
IDA: Inferred from direct assay
24792364 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10777590 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10777590 GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
24792364 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
24792364 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXJ2 Protein Structure

Forkhead

Forkhead: Forkhead domain (66 - 144)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 574 a.a.
Protein Preferred Names Protein Names

forkhead box protein J2

  • FOXJ2 forkhead factor

FOXJ2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
FOXJ2 Q9P0K8 EGLN3 Homo sapiens Q9H6Z9
Y2H Prey Pooling
25416956
Intra
FOXJ2 Q9P0K8 EGLN3 Homo sapiens Q9H6Z9
Validated Y2H
25416956
Intra
FOXJ2 Q9P0K8 EYA4 Homo sapiens O95677
TAP
25609649
Intra
FOXJ2 Q9P0K8 DLX5 Homo sapiens P56178
TAP
25609649
Intra
FOXJ2 Q9P0K8 FOXF2 Homo sapiens Q12947
TAP
25609649
Intra
FOXJ2 Q9P0K8 BBX Homo sapiens Q8WY36
TAP
25609649
Intra
FOXJ2 Q9P0K8 FOXC1 Homo sapiens Q12948
TAP
25609649
Intra
FOXJ2 Q9P0K8 ADNP Homo sapiens Q9H2P0
TAP
25609649
Intra
FOXJ2 Q9P0K8 ESS2 Homo sapiens Q96DF8
TAP
25609649
Intra
FOXJ2 Q9P0K8 EMSY Homo sapiens Q7Z589
TAP
25609649
Intra
FOXJ2 Q9P0K8 CUX1 Homo sapiens P39880
TAP
25609649
Intra
FOXJ2 Q9P0K8 AKAP8 Homo sapiens O43823
TAP
25609649
Intra
FOXJ2 Q9P0K8 CSTF2T Homo sapiens Q9H0L4
Validated Y2H
32296183
Intra
FOXJ2 Q9P0K8 FOXJ2 Homo sapiens Q9P0K8
TAP
25609649
Intra
FOXJ2 Q9P0K8 DNTTIP1 Homo sapiens Q9H147
TAP
25609649
Intra
FOXJ2 Q9P0K8 CHD4 Homo sapiens Q14839
TAP
25609649
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS05057 FOXJ2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FOXJ2 VGNC VGNC:62337
Macaca mulatta FOXJ2 VGNC VGNC:72568
Bos taurus FOXJ2 VGNC VGNC:29090
Rattus norvegicus FOXJ2 RGD RGD:1565101
Canis familiaris FOXJ2 VGNC VGNC:40955
Mus musculus FOXJ2 MGD MGI:1926805
Others FOXJ2 NCBI