TRPM8 - transient receptor potential cation channel subfamily M member 8 Gene

Also Known as TRPP8; LTRPC6; trp-p8; LTrpC-6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79054

About TRPM8

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,917,373-234,019,522 (from NCBI)

This gene has 14 transcripts (splice variants), 157 orthologues and 7 paralogues. Restricted expression toward prostate (RPKM 48.0).

Summary

Predicted to enable ligand-gated Calcium Channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TRPM8 Products (25)

mRNA Protein Name
NM_001397606.1 NP_001384535.1 transient receptor potential cation channel subfamily M member 8 isoform 2
NM_001397607.1 NP_001384536.1 transient receptor potential cation channel subfamily M member 8 isoform 3
NM_001397608.1 NP_001384537.1 transient receptor potential cation channel subfamily M member 8 isoform 4
NM_001397609.1 NP_001384538.1 transient receptor potential cation channel subfamily M member 8 isoform 5
NM_001397610.1 NP_001384539.1 transient receptor potential cation channel subfamily M member 8 isoform 5
NM_001397611.1 NP_001384540.1 transient receptor potential cation channel subfamily M member 8 isoform 5
NM_001397612.1 NP_001384541.1 transient receptor potential cation channel subfamily M member 8 isoform 6
NM_001397613.1 NP_001384542.1 transient receptor potential cation channel subfamily M member 8 isoform 6
NM_001397614.1 NP_001384543.1 transient receptor potential cation channel subfamily M member 8 isoform 8
NM_001397615.1 NP_001384544.1 transient receptor potential cation channel subfamily M member 8 isoform 8
NM_001397617.1 NP_001384546.1 transient receptor potential cation channel subfamily M member 8 isoform 10
NM_001397619.1 NP_001384548.1 transient receptor potential cation channel subfamily M member 8 isoform 9
NM_001397620.1 NP_001384549.1 transient receptor potential cation channel subfamily M member 8 isoform 11
NM_001397621.1 NP_001384550.1 transient receptor potential cation channel subfamily M member 8 isoform 11
NM_001397622.1 NP_001384551.1 transient receptor potential cation channel subfamily M member 8 isoform 11
NM_001397623.1 NP_001384552.1 transient receptor potential cation channel subfamily M member 8 isoform 12
NM_001397624.1 NP_001384553.1 transient receptor potential cation channel subfamily M member 8 isoform 13
NM_001397625.1 NP_001384554.1 transient receptor potential cation channel subfamily M member 8 isoform 14
NM_001397626.1 NP_001384555.1 transient receptor potential cation channel subfamily M member 8 isoform 15
NM_001397627.1 NP_001384556.1 transient receptor potential cation channel subfamily M member 8 isoform 16
NM_001397628.1 NP_001384557.1 transient receptor potential cation channel subfamily M member 8 isoform 17
NM_001397629.1 NP_001384558.1 transient receptor potential cation channel subfamily M member 8 isoform 17
NM_001397630.1 NP_001384559.1 transient receptor potential cation channel subfamily M member 8 isoform 17
NM_001397635.1 NP_001384564.1 transient receptor potential cation channel subfamily M member 8 isoform 7
NM_024080.5 NP_076985.4 transient receptor potential cation channel subfamily M member 8 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25559186 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in plasma membrane IDA
IDA: Inferred from direct assay
25559186 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPM8 Protein Structure

Ion_trans

Ion_trans: Ion transport protein (772 - 978)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1104 a.a.
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 8

  • TRPM8 cationic channel

TRPM8 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P810995 TRPM8 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P81864 TRPM8 Antibody (YA1609) WB, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Migraine Without Aura

  • Common Migraine

  • Migraine With Or Without Aura, Susceptibility To

  • Migraine Without Aura, Susceptibility To

  • Acute Migraine Without Aura
Photokeratitis
Dentin Sensitivity

  • Sensitive Dentin
Microcephalic Osteodysplastic Primordial Dwarfism, Type I

  • Taybi-Linder Syndrome

  • Brachymelic Primordial Dwarfism

  • Cephaloskeletal Dysplasia

  • Low-Birth-Weight Dwarfism With Skeletal Dysplasia

  • Microcephalic Osteodysplastic Primordial Dwarfism Type I

  • Osteodysplastic Primordial Dwarfism Type I

  • Primordial Microcephalic Dwarfism, Crachami Type

  • Osteodysplastic Primordial Dwarfism, Type 1

  • MOPD1

  • Mopd I

  • Mopd

  • Osteodysplastic Primordial Dwarfism, Type I

  • Tals

  • Microcephalic Osteodysplastic Primordial Dwarfism Type 1

  • Mopd 1

  • Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3

  • Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii

  • Mopd Types I And Iii

  • Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type

  • Primordial Microcephalic Dwarfism Crachami Type

  • Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1
Diabetic Neuropathy

  • Diabetic Neuropathies
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Lichen Sclerosus Et Atrophicus

  • Lichen Sclerosus

  • LSA

  • Lichen Sclerosis

  • Lichen Sclerosis Et Atrophicus

  • Ls Et A - [Lichen Sclerosus Et Atrophicus]

  • Lichen Albus
Familial Episodic Pain Syndrome

  • Feps
Lymph Node Carcinoma

  • Lymph Node Cancer

  • Lymph Node Neoplasm

  • Neoplasm Of Lymph Node
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

  • Olmsted Syndrome

  • Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques

  • Palmoplantar And Periorificial Keratoderma

  • Olms
Atrophic Rhinitis

  • Rhinitis, Atrophic

  • Ozena

  • Rhinitis Sicca

  • Dry Rhinitis

  • Ozaena
Somatoform Disorder

  • Physiological Malfunction Arising From Mental Factor

  • Psychosomatic Disorder

  • Psychophysiologic Disorders
Trigeminal Nerve Disease

  • Trigeminal Nerve Diseases

  • Disorders Of 5th Cranial Nerve

  • Disorders Of The Fifth Cranial Nerve
Lacrimal Apparatus Disease

  • Lacrimal Apparatus Diseases
Pain Agnosia

  • Analgesia
Paine Syndrome

  • Pain Disorder

  • Pain

  • Microcephaly With Spastic Diplegia

  • Pain Syndrome
Agnosia

  • Dyspraxia

  • Primary Visual Agnosia

  • Dyspraxia Syndrome

  • Monomodal Visual Amnesia

  • Visual Amnesia

  • Agnosia, Primary Visual

  • Apraxias

  • Alexia
Dry Eye Syndrome

  • Dry Eye Syndromes

  • Dry Eye Disease

  • Tear Film Insufficiency

  • Xerophthalmia
Ocular Hyperemia

  • Hyperemia Eye

  • Hyperemia Of Conjunctiva
Complex Regional Pain Syndrome

  • Complex Regional Pain Syndromes

  • Reflex Sympathetic Dystrophy

  • Crps
Trigeminal Neuralgia

  • Tic Douloureux

  • Trifacial Neuralgia

  • Trifocal Neuralgia

  • Neuralgia Of The Fifth Cranial Nerve

  • Neuralgia Of 5th Cranial Nerve

  • Infraorbital Neuralgia
Interstitial Cystitis

  • Bladder Pain Syndrome

  • Painful Bladder Syndrome

  • Ulcerative Cystitis

  • Ic/Bps

  • Ic/Pbs

  • Interstitial Cystitis/Bladder Pain Syndrome

  • Interstitial Cystitis/Painful Bladder Syndrome

  • Cystitis, Interstitial

  • Chronic Interstitial Cystitis

  • Pelvic Congestion Syndrome

  • Trigonitis
Erythromelalgia

  • Primary Erythromelalgia

  • Erythermalgia

  • Primary Erythermalgia

  • Mitchell Disease

  • Familial Erythromelalgia
Paroxysmal Extreme Pain Disorder

  • PEPD

  • Familial Rectal Pain

  • Pexpd

  • Submandibular, Ocular, And Rectal Pain With Flushing

  • Pain, Submandibular, Ocular, And Rectal, With Flushing

  • Rectal Pain, Familial

  • Submandibular, Ocular And Rectal Pain With Flushing

  • Familial Rectal Syndrome

  • Frp

  • Pain Disorder, Paroxysmal, Extreme
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Migraine With Aura

  • Classic Migraine

  • Migraine With Typical Aura

  • Migraine Accompagnée

  • Complicated Migraine

  • Classical Migraine

  • Acute Migraine With Aura
Lennox-Gastaut Syndrome

  • Lennox Syndrome

  • Encephalopathy Of Childhood

  • Epileptic Encephalopathy Lennox-Gastaut Type

  • Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

  • Lgs
Peripheral Nervous System Disease

  • Peripheral Neuropathy

  • Peripheral Nerve Disease

  • Peripheral Nerve Disorders

  • Neuropathy, Peripheral

  • Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-108449 Acoltremon Agonist 99.13% Unkown

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-109087 Elismetrep Antagonist 99.59% Phase 2
HY-115506 PF-05105679 Antagonist 99.88% Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-11062 Icilin Agonist 99.26% Unkown
HY-18662 RQ-00203078 Antagonist 99.84% Unkown
HY-19976 RN-1747 Modulator 99.27% Unkown
HY-110181 M8-B Antagonist 99.74% Unkown
HY-144372 TRPV1 antagonist 3 Antagonist 99.30% Unkown
HY-N7144A Citronellyl acetate 98.0% Unkown
HY-N7117 1,4-Cineole Activator 95.0% Unkown
HY-108461 TRPM8-IN-1 Inhibitor 99.44% Unkown
HY-172774 TRPV1 antagonist 10 Antagonist 98.54% Unkown
HY-141712 ZA18 Inhibitor 99.72% Unkown
HY-170302 CMP233 Inhibitor 99.10% Unkown
HY-W014394 Vanillyl butyl ether Agonist 99.75% Unkown
HY-174825 TRPM8 antagonist 4 Antagonist / Unkown
HY-168471 AAL-149 Inhibitor / Unkown
HY-179432 Cannabitwinol Modulator / Unkown
HY-174846 TRPM8 antagonist 4 prodrug Antagonist / Unkown
HY-177763 TRPM8 receptor agonist-1 Agonist / Unkown
HY-117372 DFL23448 Antagonist / Unkown
HY-185173 (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TRPM8 MGD MGI:2181435
Felis catus TRPM8 VGNC VGNC:82512
Bos taurus TRPM8 VGNC VGNC:36394
Macaca mulatta TRPM8 VGNC VGNC:99415
Canis familiaris TRPM8 VGNC VGNC:47879
Rattus norvegicus TRPM8 RGD RGD:620762
Others TRPM8 NCBI