2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide 

製品番号: HY-185173
取扱説明書 Technical Support

(E)-3-Benzodioxol-5-yl-N,N-diphenyl-2-propenamide is a chemically synthesized flavoring substance and can be found in toothpaste products. (E)-3-Benzodioxol-5-yl-N,N-diphenyl-2-propenamide is non-genotoxic, shows no genotoxic activity in bacterial reverse mutation and in vitro mammalian cell micronucleus assays. (E)-3-Benzodioxol-5-yl-N,N-diphenyl-2-propenamide does not induce prenatal developmental toxicity in rats.

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(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide 構造式

CAS 番号 : 1309389-73-8

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(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide 関連抗体

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TRP Channel アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

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製品説明

(E)-3-Benzodioxol-5-yl-N,N-diphenyl-2-propenamide is a chemically synthesized flavoring substance and can be found in toothpaste products. (E)-3-Benzodioxol-5-yl-N,N-diphenyl-2-propenamide is non-genotoxic, shows no genotoxic activity in bacterial reverse mutation and in vitro mammalian cell micronucleus assays. (E)-3-Benzodioxol-5-yl-N,N-diphenyl-2-propenamide does not induce prenatal developmental toxicity in rats[1].

IC50 & Target

TRPM8

 

体外実験

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide (22-5500 μg/plate) does not exhibit mutagenic activity in the bacterial reverse mutation assay across Salmonella Typhimurium and Escherichia coli strains[1].
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide (2-100 μg/mL, 3-24 h) does not induce clastogenicity or aneugenicity in human peripheral blood lymphocytes in the in vitro micronucleus test[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide 関連抗体
体内実験

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide (30-500 mg/kg bw per day; oral, dietary; daily; 90 days) induces decreases in total WBC count in rats, with a BMDL of 101 mg/kg bw per day for females[1].
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide (10-1000 mg/kg bw per day; oral, dietary; daily; 14 days) is well tolerated by rats at doses up to 1000 mg/kg bw per day for 14 days[1].
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide (125-1000 mg/kg bw per day; oral, gavage; daily; 15 days) does not induce prenatal developmental toxicity in rats at doses up to 1000 mg/kg bw per day[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CRL Sprague-Dawley CD® IGS rats (pregnant females)[1]
Dosage: 125, 250, 500, 1000 mg/kg bw per day
Administration: Oral, gavage; daily; 15 days (gestation days 5-19)
Result: Reported no mortality, treatment-related effects on body weight, uterine/reproductive parameters, or fetal visceral/skeletal malformations/developmental variations.
Noted incidental clinical signs (alopecia, nose lesion) in some animals that were not treatment-related.
分子量

343.38

分子式

C22H17NO3
CAS 番号
SMILES

O=C(N(C1=CC=CC=C1)C2=CC=CC=C2)/C=C/C3=CC=C(OCO4)C4=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide1309389-73-8TRP ChannelTransient receptor potential channelsclastogenicitygenotoxic activityhuman peripheral blood lymphocytesdevelopmental toxicityEscherichia colimutagenic activityInhibitorinhibitorinhibit

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