2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide 

Cat. No.: HY-185173
Handling Instructions Technical Support

(E)-3-Benzodioxol-5-yl-N,N-diphenyl-2-propenamide is a chemically synthesized flavoring substance and can be found in toothpaste products. (E)-3-Benzodioxol-5-yl-N,N-diphenyl-2-propenamide is non-genotoxic, shows no genotoxic activity in bacterial reverse mutation and in vitro mammalian cell micronucleus assays. (E)-3-Benzodioxol-5-yl-N,N-diphenyl-2-propenamide does not induce prenatal developmental toxicity in rats.

For research use only. We do not sell to patients.

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide Chemical Structure

CAS No. : 1309389-73-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide Related Antibodies

Top Publications Citing Use of Products

View All TRP Channel Isoform Specific Products:

View All Isoforms
TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(E)-3-Benzodioxol-5-yl-N,N-diphenyl-2-propenamide is a chemically synthesized flavoring substance and can be found in toothpaste products. (E)-3-Benzodioxol-5-yl-N,N-diphenyl-2-propenamide is non-genotoxic, shows no genotoxic activity in bacterial reverse mutation and in vitro mammalian cell micronucleus assays. (E)-3-Benzodioxol-5-yl-N,N-diphenyl-2-propenamide does not induce prenatal developmental toxicity in rats[1].

IC50 & Target

TRPM8

 

In Vitro

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide (22-5500 μg/plate) does not exhibit mutagenic activity in the bacterial reverse mutation assay across Salmonella Typhimurium and Escherichia coli strains[1].
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide (2-100 μg/mL, 3-24 h) does not induce clastogenicity or aneugenicity in human peripheral blood lymphocytes in the in vitro micronucleus test[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide Related Antibodies
In Vivo

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide (30-500 mg/kg bw per day; oral, dietary; daily; 90 days) induces decreases in total WBC count in rats, with a BMDL of 101 mg/kg bw per day for females[1].
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide (10-1000 mg/kg bw per day; oral, dietary; daily; 14 days) is well tolerated by rats at doses up to 1000 mg/kg bw per day for 14 days[1].
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide (125-1000 mg/kg bw per day; oral, gavage; daily; 15 days) does not induce prenatal developmental toxicity in rats at doses up to 1000 mg/kg bw per day[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CRL Sprague-Dawley CD® IGS rats (pregnant females)[1]
Dosage: 125, 250, 500, 1000 mg/kg bw per day
Administration: Oral, gavage; daily; 15 days (gestation days 5-19)
Result: Reported no mortality, treatment-related effects on body weight, uterine/reproductive parameters, or fetal visceral/skeletal malformations/developmental variations.
Noted incidental clinical signs (alopecia, nose lesion) in some animals that were not treatment-related.
Molecular Weight

343.38

Formula

C22H17NO3
CAS No.
SMILES

O=C(N(C1=CC=CC=C1)C2=CC=CC=C2)/C=C/C3=CC=C(OCO4)C4=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide1309389-73-8TRP ChannelTransient receptor potential channelsclastogenicitygenotoxic activityhuman peripheral blood lymphocytesdevelopmental toxicityEscherichia colimutagenic activityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
(E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide
Cat. No.:
HY-185173
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.