LSD1/2-IN-3
LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 11 nM instead of 7 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, LSD1/2-IN-1 inhibits LSD1 cell proliferation.
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- CAS. Nr.: 2821068-07-7
- Formel: C9H8BrF2N
- Molecular Weight:248.07
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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KDM1/LSD1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
25 μM
Compound: 8c
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Anti-proliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by AlamarBlue assay
Anti-proliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by AlamarBlue assay
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[PMID: 36105323] |
| Jurkat | IC50 |
27 μM
Compound: 8c
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Anti-proliferative activity against human Jurkat cells assessed as reduction in cell viability after 72 hrs by AlamarBlue assay
Anti-proliferative activity against human Jurkat cells assessed as reduction in cell viability after 72 hrs by AlamarBlue assay
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[PMID: 36105323] |
| WI-38 | IC50 |
>50 μM
Compound: 8c
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Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 72 hrs by AlamarBlue assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 72 hrs by AlamarBlue assay
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[PMID: 36105323] |
LSD1/2-IN-3 (compound 8c) inhibits proliferation of the T-cell acute lymphoblastic leukemia (T-ALL) with IC50s of 25 μM (CCRF-CEM) and 27 μM (Jurkat), respectively, without inhibiting the human normal fibroblast cell line WI-38[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2821068-07-7
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Molecular Weight 248.07
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Formel C9H8BrF2N
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SMILES
N[C@@H]1C[C@@H]1C2=CC(F)=C(Br)C(F)=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
LSD1/2-IN-3 Related Classifications
HY-151192 Related Classifications
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