MAP3K6/ASK2
MAP3K6 (ASK2) is the closest paralog of ASK1 within the STE11 group and functions largely as its heterodimerization partner, forming ASK1-ASK2 complexes whose activity and stress responsiveness differ from those of ASK1 homodimers. ASK2 can phosphorylate MKK3/6 and MKK4/7, but its independent signaling output is weaker, and evidence points to roles in modulating oxidative-stress, osmotic-stress and apoptotic responses in epithelial tissues, where its expression is prominent. Reduced ASK2 levels have been reported in skin and other epithelial cancers, suggesting a growth-suppressive function. Recombinant ASK2 is used to reconstitute ASK-family heterocomplexes and dissect their differential regulation.
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MAP3K6/ASK2 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
