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Art. -Nr.: HY-118707

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Trimethionine

Name: Trimethionine
Brand: MedChemExpress
SKU: HY-118707
Availability: PreOrder

(Synonyms: Met-met-met)

Trimethionine (Met-met-met) is an orally active tripeptide substrate of peptide transport systems. Trimethionine interacts with the triple-leucine-triple-threonine transport system and the oligopeptide permease (Opp) system in Escherichia coli, competing for uptake and transport processes. Trimethionine antagonizes the toxicity of threonine tripeptide and ornithine tripeptide, and competes with peptide-supported growth and amino acid source utilization processes in Escherichia coli strains. Trimethionine is taken up by Candida albicans via a carrier-mediated, energy-dependent manner, and is subsequently hydrolyzed into free methionine intracellularly. Trimethionine can be used in studies related to Candida albicans infections.

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CAS. Nr.: 14486-15-8
Formel: C₁₅H₂₉N₃O₄S₃
Molecular Weight:411.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Trimethionine Chemical Structure

CAS. Nr.: 14486-15-8

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Biologische Aktivität

Beschreibung

In Vitro

Protein/Amino Acid Metabolism

Trimethionine competes with trileucine for utilization by the Opp⁺ and Opp^- strains of Escherichia coli K-12 TD-V, indicating that it can be recognized by the trileucine-threonine transport system^[1].
Trimethionine can be transported via the general oligopeptide transport system (Opp) in Escherichia coli W M-26-26, as it alleviates triornithine toxicity through competitive uptake inhibition^[1].
Trimethionine competes with tetra-lysine for utilization in Escherichia coli W M-26-26, confirming that it is a substrate of the general oligopeptide transport system (Opp)^[1].
Trimethionine is taken up by Candida albicans WD 18-4 via a saturable, energy-dependent carrier-mediated system; upon uptake, it is rapidly hydrolyzed to free methionine by intracellular peptidases immediately^[3].
The transport system for Trimethionine in Candida albicans WD 18-4 is highly specific, and it strongly recognizes tripeptides with hydrophobic side chains, an N-terminal acetyl group, or a D-type residue at the first position^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Protein/Amino Acid Metabolism

Trimethionine (3.00% (methionine level in nitrogen source); diet feeding; daily; 14 days) delivered via a SPI-based diet achieves a significantly high protein efficiency ratio (3.21) and supports healthy growth in young male Wistar rats over 14 days^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male, 4 weeks old)^[2]
Dosage:

3.00% (methionine level in nitrogen source)
Administration:

diet feeding; daily; 14 days
Result:

Achieved a protein efficiency ratio (PER) of 3.21.
Supported a growth rate comparable to that of rats fed diets supplemented with free methionine or dimethionine over the 14-day feeding period.

Chemical Information

CAS. Nr. 14486-15-8
Molecular Weight 411.59
Formel C₁₅H₂₉N₃O₄S₃
SMILES

[C@H](C(N[C@@H](CCSC)C(O)=O)=O)(NC([C@H](CCSC)N)=O)CCSC
Synonyms

Met-met-met
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Barak Z, et al. Specialized peptide transport system in Escherichia coli. Journal of bacteriology. 1975 Jun;122(3):1200-7. [Content Brief]

[2]. Arai S, et al. Bioavailability of L-Methionine Oligomers in Rats. Agricultural and Biological Chemistry, 1988, 52(7): 1873-1875.

[3]. Logan D A, et al. Peptide Transport in Candida albicans. Journal of General Microbiology, 1979, 114: 179-186.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

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Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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