HCN Channel Modulator
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Org 34167 (freebase)
0 ImagesCat. No.: HY-182459CAS No.: 198968-25-1Org 34167 freebase is a blood-brain barrier permeable HCN channel modulator. Org 34167 freebase possesses high Caco-2 cell permeability. Org 34167 freebase modulates HCN channel function to alter activation properties and suppress neuronal hyperexcitability. Org 34167 freebase induces tremors in mice at specific doses. Org 34167 freebase acts as a research tool for studies on developmental and epileptic encephalopathies as well as depression.
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KIO-301
0 ImagesCat. No.: HY-160209CAS No.: 1643463-61-9KIO-301 is a photosensitizer with selective retinal ganglion cell uptake properties. KIO-301 acts on HCN channels and endogenous voltage-gated cation channels, thereby enabling photoswitch-mediated photoresponses and light-driven action potential generation. KIO-301 confers rapid and reliable light-evoked spike responses in retinal explants from mouse models of retinal degeneration, producing sustained light-evoked responses. KIO-301 can be used in research related to retinal degeneration.
