CHGB - chromogranin B Gene

Also Known as SCG1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1114

About CHGB

Cytogenetic location: 20p12.3 Genomic coordinates (GRCh38): 20:5,911,510-5,925,353 (from NCBI)

This gene has 3 transcripts (splice variants), 122 orthologues and 1 paralogue. Biased expression in adrenal (RPKM 1898.3) and stomach (RPKM 91.0).

Summary

This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]

CHGB Products (1)

mRNA	Protein	Name
NM_001819.3	NP_001810.2	secretogranin-1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHGB Protein Structure

Granin

0
200
400
600
677 a.a.

Protein Preferred Names	Protein Names
secretogranin-1	cgB

CHGB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CHGB	P05060	SMAD2	Homo sapiens	Q15796	Display Tech	20195357
Intra	CHGB	P05060	LRRK2	Homo sapiens	Q5S007	Protein Array	24947832
Intra	CHGB	P05060	LRRK2	Homo sapiens	Q5S007	Protein Array	29513927

Cross: Cross-species interaction Intra: Intraspecies interaction

CHGB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82677	Chromogranin B Antibody (YA2422)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Neuroendocrine Tumor	Neuroendocrine Neoplasm Neuroendocrine Tumors Carcinoma, Neuroendocrine
Glucagonoma	Glucagonoma Syndrome Pancreatic Glucagonoma
Multiple Endocrine Neoplasia	Men Multiple Endocrine Adenomatosis Multiple Endocrine Neoplasia Syndrome Adenomatosis, Familial Endocrine Endocrine Neoplasia, Multiple Familial Endocrine Adenomatosis Mea Multiple Endocrine Neoplasms Multiple Endocrine Neoplasia Type 1
Paraganglioma	Chemodectoma Glomus Body Tumor Paragangliomas Carotid Body Paraganglioma Extra-Adrenal Paraganglioma
Carcinoid Tumors, Intestinal	Carcinoid Gastrointestinal Carcinoid Tumor Argentaffinoma Intestinal Carcinoid Tumor ICT Tumor, Carcinoid, Intestinal Malignant Carcinoid Syndrome Carcinoid Tumor Of Intestine Carcinoid Tumor Carcinoid Tumor No Icd-O Subtype
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1	Eec Syndrome Rudiger Syndrome 1 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1 EEC1 Eec Syndrome 1 Eec Syndrome-1 Walker-Clodius Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome Eec Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly-Cleft Lip/Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome Ectrodactyly-Cleft Lip-Palate Syndrome Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Parathyroid Adenoma	Adenoma Of Parathyroid Adenoma Of The Parathyroid Gland Parathyroid Gland Adenoma
Temporal Lobe Epilepsy	Epilepsy, Temporal Lobe Epilepsy Temporal Lobe
Mixed Ductal-Endocrine Carcinoma
Prolactinoma	Prolactin-Producing Pituitary Gland Adenoma Prolactin-Secreting Pituitary Adenoma Forbes-Albright Syndrome Lactotroph Adenoma Prl-Secreting Pituitary Adenoma Prloma Pituitary Lactotrophic Adenoma Familial Prolactinoma Pituitary Adenoma, Prolactin-Secreting Prolactinoma Of Pituitary Gland PSPA
Colon Neuroendocrine Neoplasm	Colonic Neuroendocrine Tumor
Gallbladder Small Cell Carcinoma	Oat Cell Carcinoma Of The Gallbladder Gallbladder Small Cell Neuroendocrine Carcinoma
Adrenal Neuroblastoma	Neuroblastoma Of Adrenal Gland Adrenal Gland Neuroblastoma Neuroblastoma Nos
Primary Hyperparathyroidism	Familial Primary Hyperparathyroidism Hyperparathyroidism, Primary Hyperparathyroidism Primary Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Benign Hypercalcemia Familial Hyperparathyroidism Parathyroid Enlargement
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02625	CHGB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22117	Chgb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28639	Chgb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CHGB	RGD	RGD:2339
Bos taurus	CHGB	VGNC	VGNC:27290
Canis familiaris	CHGB	VGNC	VGNC:39212
Macaca mulatta	CHGB	VGNC	VGNC:71033
Mus musculus	CHGB	MGD	MGI:88395
Felis catus	CHGB	VGNC	VGNC:60855
Others	CHGB	NCBI