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DTX1 - deltex E3 ubiquitin ligase 1 Gene

Also Known as hDx-1; RNF140

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1840

About DTX1

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:113,056,730-113,098,025 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 4 paralogues. Broad expression in lymph node (RPKM 13.1), spleen (RPKM 9.7) and 18 other tissues.

Summary

Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]

DTX1 Products (1)

mRNA	Protein	Name
NM_004416.3	NP_004407.2	E3 ubiquitin-protein ligase DTX1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables Notch binding	IDA IDA: Inferred from direct assay	11564735	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7671825	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	17028573	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	11564735	GOA
involved in regulation of Notch signaling pathway	IGI IGI: Inferred from genetic interaction	11564735	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DTX1 Protein Structure

WWE

zf-RING_2

0
100
200
300
400
500
620 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase DTX1	RING-type E3 ubiquitin transferase DTX1

DTX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DTX1	Q86Y01	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	17028573

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Familial Pityriasis Rubra Pilaris	Familial Prp Pityriasis Rubra Pilaris--Familial Type
Pityriasis Rubra Pilaris	PRP Devergie'S Disease Prp - [Pityriasis Rubra Pilaris]
N1 Diffuse Large B-Cell Lymphoma	N1 Dlbcl Doid:0081067
Arteriovenous Malformations Of The Brain	Cerebral Arteriovenous Malformation Intracranial Arteriovenous Malformation Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To Intracranial Arteriovenous Malformations Bavm Cerebral Arteriovenous Malformations Intracranial Hemorrhage In Brain Cerebrovascular Malformations Arteriovenous Malformation Of The Brain, Somatic Intracranial Avm Arteriovenous Malformations Cerebral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126931	Dinophysistoxin 1		95.00%	Unkown
HY-RS04038	DTX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18353	Dtx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24832	Dtx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DTX1	RGD	RGD:1585380
Felis catus	DTX1	VGNC	VGNC:61648
Macaca mulatta	DTX1	VGNC	VGNC:108340
Mus musculus	DTX1	MGD	MGI:1352744
Bos taurus	DTX1	VGNC	VGNC:28236
Others	DTX1	NCBI