GRINA - glutamate ionotropic receptor NMDA type subunit associated protein 1 Gene

Also Known as LFG1; HNRGW; TMBIM3; NMDARA1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2907

About GRINA

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,990,056-143,993,415 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues and 5 paralogues. Ubiquitous expression in fat (RPKM 80.7), brain (RPKM 68.3) and 25 other tissues.

Summary

Predicted to enable transmembrane transporter binding activity. Predicted to act upstream of or within endoplasmic reticulum calcium ion homeostasis and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

GRINA Products (2)

mRNA Protein Name
NM_000837.2 NP_000828.1 protein lifeguard 1
NM_001009184.2 NP_001009184.1 protein lifeguard 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRINA Protein Structure

Bax1-I

Bax1-I: Inhibitor of apoptosis-promoting Bax1 (159 - 365)

  • 0
  • 100
  • 200
  • 300
  • 371 a.a.
Protein Preferred Names Protein Names

protein lifeguard 1

  • NMDA receptor glutamate-binding subunit

GRINA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GRINA Q7Z429 TMEM242 Homo sapiens Q9NWH2
Y2H Prey Pooling
32296183
Intra
GRINA Q7Z429 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra
GRINA Q7Z429 TMEM242 Homo sapiens Q9NWH2
Y2H Array
32296183
Intra
GRINA Q7Z429 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra
GRINA Q7Z429 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra
GRINA Q7Z429 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
GRINA Q7Z429 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
GRINA Q7Z429 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
GRINA Q7Z429 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
GRINA Q7Z429 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
GRINA Q7Z429 FMO1 Homo sapiens Q01740
Y2H Array
32296183
Intra
GRINA Q7Z429 FMO1 Homo sapiens Q01740
Y2H Prey Pooling
32296183
Intra
GRINA Q7Z429 GGT6 Homo sapiens Q6P531
Y2H Prey Pooling
32296183
Intra
GRINA Q7Z429 GGT6 Homo sapiens Q6P531
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05808 GRINA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GRINA VGNC VGNC:67474
Bos taurus GRINA VGNC VGNC:29651
Rattus norvegicus GRINA RGD RGD:628873
Canis familiaris GRINA VGNC VGNC:41497
Mus musculus GRINA MGD MGI:1913418
Others GRINA NCBI