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EIF6 - eukaryotic translation initiation factor 6 Gene

Also Known as CAB; EIF3A; eIF-6; p27BBP; ITGB4BP; b(2)gcn; p27(BBP)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3692

About EIF6

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,278,906-35,284,772 (from NCBI)

This gene has 9 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in esophagus (RPKM 55.8), duodenum (RPKM 45.2) and 25 other tissues.

Summary

Hemidesmosomes are structures which link the basal lamina to the intermediate filament Cytoskeleton. An important functional component of hemidesmosomes is the Integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament Cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

EIF6 Products (4)

mRNA	Protein	Name
NM_001267810.1	NP_001254739.1	eukaryotic translation initiation factor 6 isoform a
NM_002212.4	NP_002203.1	eukaryotic translation initiation factor 6 isoform a
NM_181466.3	NP_852131.1	eukaryotic translation initiation factor 6 isoform c
NM_181468.2	NP_852133.1	eukaryotic translation initiation factor 6 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17507929	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	21536732	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytosolic ribosome assembly	IMP IMP: Inferred from mutant phenotype	21536732	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IMP IMP: Inferred from mutant phenotype	17507929	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IMP IMP: Inferred from mutant phenotype	17507929	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12426392	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12426392	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF6 Protein Structure

eIF-6

0
100
200
245 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 6	B4 integrin interactor

EIF6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EIF6	P56537	MSRB3	Homo sapiens	Q8IXL7-2	Validated Y2H	32296183
Intra	EIF6	P56537	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	EIF6	P56537	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	EIF6	P56537	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	EIF6	P56537	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	EIF6	P56537	VAC14	Homo sapiens	Q08AM6	Validated Y2H	32296183
Intra	EIF6	P56537	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Cross	EIF6	P56537	Prkcb	Mus musculus	P68404	Protein Kinase Assay	21665150
Intra	EIF6	P56537	EIF2AK2	Homo sapiens	P19525	Anti Tag CoIP	21903422
Intra	EIF6	P56537	NREP	Homo sapiens	Q16612	Anti Bait CoIP	22365962
Intra	EIF6	P56537	NREP	Homo sapiens	Q16612	Y2H	22365962

Cross: Cross-species interaction Intra: Intraspecies interaction

EIF6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87155	eIF-6 Antibody (YA6848)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Shwachman-Diamond Syndrome 1	Shwachman-Diamond Syndrome Shwachman Syndrome Shwachman-Bodian-Diamond Syndrome Sds Pancreatic Insufficiency And Bone Marrow Dysfunction Shwachman-Bodian Syndrome SDS1 Lipomatosis Of Pancreas, Congenital Congenital Lipomatosis Of Pancreas Shwachman-Diamond Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia, Shwachman Type Shwachman-Diamond-Oski Syndrome
Exocrine Pancreatic Insufficiency
Bowen-Conradi Syndrome	BWCNS Bowen Hutterite Syndrome Bowen-Conradi Hutterite Syndrome Bowen Syndrome, Hutterite Type Bowen Hutterite Syndrome, Formerly Hutterite Syndrome Bowen Syndrome Hutterite Type Fetal Growth Retardation
Anauxetic Dysplasia 1	Anauxetic Dysplasia Spondylometaepiphyseal Dysplasia, Menger Type Spondylometaepiphyseal Dysplasia, Anauxetic Type Spondyloepimetaphyseal Dysplasia, Anauxetic Type ANXD1 Anxd Spondylometaepiphyseal Dysplasia Anauxetic Type Spondylometaepiphyseal Dysplasia Menger Type Ad Spondyloepimetaphyseal Dysplasia, Menger Type Dysplasia, Anauxetic, Type 1
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04289	EIF6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EIF6	VGNC	VGNC:57006
Mus musculus	EIF6	MGD	MGI:1196288
Felis catus	EIF6	VGNC	VGNC:80091
Rattus norvegicus	EIF6	RGD	RGD:1305373
Macaca mulatta	EIF6	VGNC	VGNC:84765
Canis familiaris	EIF6	VGNC	VGNC:54648
Others	EIF6	NCBI