Based on 1 Customer Validation
IBMX (3-Isobutyl-1-methylxanthine) (GMP) is IBMX (HY-12318) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 28822-58-4
- Formula: C10H14N4O2
- Molecular Weight:222.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
466 μM
Compound: IBMX
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Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit
Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit
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[PMID: 22761000] |
| Oocyte | IC50 |
970 μM
Compound: 3-Isobutyl-1-methylxanthine
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TP_TRANSPORTER: inhibition of L-Lactate uptake (L-Lactate:30mM) in Xenopus laevis oocytes
TP_TRANSPORTER: inhibition of L-Lactate uptake (L-Lactate:30mM) in Xenopus laevis oocytes
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[PMID: 11101640] |
| Sf21 | IC50 |
4 μM
Compound: IBMX; CHEMBL275084
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Inhibition of human C-terminal His6-tagged PDE2A1 (215 to 900 residues) expressed in sf21 cells
Inhibition of human C-terminal His6-tagged PDE2A1 (215 to 900 residues) expressed in sf21 cells
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[PMID: 26908025] |
IBMX (0.5 mM) induces neural-like cells for neural differentiation of cord blood derived mesenchymal-like stem cells[1]. IBMX induces initiation of the differentiation of programpre-adipocytes[2]. IBMX (500 μM) induces neuronal differentiation of small cell lung cancer[3]. IBMX (100 μM) induces differentiation of 3T3-LI adipocytes[4]. IBMX (500 μM) induces adipose tissue-derived stem cells (ADSC) differentiate into neuron-like cells[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 28822-58-4
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Appearance Solid
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Molecular Weight 222.24
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Formula C10H14N4O2
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Color White to off-white
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SMILES
O=C(N1C)N(CC(C)C)C2=C(N=CN2)C1=O
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Synonyms
3-Isobutyl-1-methylxanthine (GMP); Isobutylmethylxanthine (GMP)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Tio M, et al. Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells. PLoS One. 2010 Feb 24;5(2):e9398. [Content Brief]
[2]. Kim SP, et al. Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation. Biochem Biophys Res Commun. 2010 Aug 13;399(1):55-9. [Content Brief]
[3]. Lange A, et al. Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro. Lung Cancer. 2011 Nov;74(2):178-87. [Content Brief]
[4]. Elks ML, Manganiello VC. A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1 adipocytes. J Cell Physiol. 1985 Aug;124(2):191-8. [Content Brief]
[5]. Ning H, et al. Insulin growth factor signaling mediates neuron-like differentiation of adipose-tissue-derived stem cells. Differentiation. 2008 May;76(5):488-94. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IBMX (GMP) Related Classifications
HY-12318G Related Classifications
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