ME67
ME67 (EM-B enol ether) is a motilin receptor (Motilin Receptor) agonist with pIC50 values of 8.38 and 6.49 for rabbit and human motilin receptors, respectively. ME67 activates the G protein-coupled Motilin Receptor, inducing calcium mobilization, calcium flux, receptor internalization, and gastrointestinal motility. ME67 can be used in research on gastrointestinal motility disorders.
For research use only. We do not sell to patients.
- CAS No.: 33275-72-8
- Formula: C37H65NO11
- Molecular Weight:699.91
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
ME67 induces calcium ion release in CHO-K1 cells expressing the human motilin receptor, with a pEC50 of 8.12[1].
ME67 contracts rabbit duodenal segments with a pEC50 of 7.11 and binds to rabbit antral motilin receptors with a pIC50 of 8.38[1].
ME67 activates Ca2+ flux in CHO-K1 cells expressing human MTLR and apoaequorin, with a pEC50 of 8.12, and desensitizes the subsequent motilin response with a pDC50 of 6.03[2].
ME67 (10−12-10−4 M; 60 min) binds to the human motilin receptor in CHO-MTLR membranes with a pIC50 of 6.49[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 33275-72-8
-
Molecular Weight 699.91
-
Formula C37H65NO11
-
SMILES
C[C@]1(OC([C@@H]([C@H]([C@H]([C@H](OC([C@@H]([C@H]([C@@H]2C)O[C@H]3C[C@](C)([C@H]([C@@H](O3)C)O)OC)C)=O)CC)C)O)C)=C(C1)C)[C@@H]2O[C@H]4[C@@H]([C@H](C[C@H](O4)C)N(C)C)O
-
Synonyms
EM-B enol ether
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Thielemans L, et al. The motilin pharmacophore in CHO cells expressing the human motilin receptor. Biochemical and biophysical research communications. 2002 May 17;293(4):1223-7. [Content Brief]
[2]. Thielemans L, et al. Desensitization of the human motilin receptor by motilides. The Journal of pharmacology and experimental therapeutics. 2005 Jun;313(3):1397-405. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ME67 Related Classifications
HY-187989 Related Classifications
Powered by Bioz