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Cat. No.: HY-144281

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MsbA-IN-3

MsbA-IN-3 (compound 31) is a potent and highly selective MsbA inhibitor with an IC₅₀ value of 2 nM. MsbA-IN-3 has inhibitory activity against Escherichia coli with a MIC of 35 μM.

For research use only. We do not sell to patients.

CAS No.: 2909443-78-1
Formula: C₂₄H₂₂Cl₂N₂O₄S
Molecular Weight:505.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

MsbA-IN-3 Chemical Structure

CAS No.: 2909443-78-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

MsbA-IN-3 (compound 31) is a potent and highly selective MsbA inhibitor with an IC₅₀ value of 2 nM. MsbA-IN-3 has inhibitory activity against Escherichia coli with a MIC of 35 μM^[1].

IC₅₀ & Target

IC₅₀: 2 nM (MsbA)^[1]

Chemical Information

CAS No. 2909443-78-1
Molecular Weight 505.41
Formula C₂₄H₂₂Cl₂N₂O₄S
SMILES

O=C(NS(=O)(C)=O)/C=C/C1=C(C2CC2)C3=CC(O[C@H](C4=C(Cl)C=CC=C4Cl)C)=CC=C3N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Verma VA, et al. Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity. J Med Chem. 2022;65(5):4085-4120. [Content Brief]

Calculators

Molarity Calculator

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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