Qc1
Based on 1 Customer Validation
Qc1 is a reversible and noncompetitive threonine dehydrogenase (TDH) inhibitor. Qc1 can be used for the research of Metabolic disease.
For research use only. We do not sell to patients.
- Purity: 98.20%
- CAS No.: 403718-45-6
- Formula: C23H16F3N3O2S
- Molecular Weight:455.45
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
TDH[1]
Qc1 (10 μM; 2~24 hours; ES cells) shows that a substantial fraction of the total LC3 protein is in the LC3-I (cytoplasmic) form. After 16 h of TDH inhibition, most LC3 is converted to the LC3-II (lipid-modified) form, indicative of increased autophagic activity[2].
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Qc1 blocks the charging of tetrahydrofolate. Qc1 prevents threonine dehydrogenase from catabolizing threonine into acetyl-CoA and glycine[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 403718-45-6
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Appearance Solid
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Molecular Weight 455.45
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Formula C23H16F3N3O2S
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Color White to off-white
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SMILES
O=C(C1=CC(NC(N2C3=CC=CC(C(F)(F)F)=C3)=S)=C(C=C1)C2=O)NCC4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 62.5 mg/mL (137.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang J, et al. Metabolic specialization of mouse embryonic stem cells. Cold Spring Harb Symp Quant Biol. 2011;76:183-193. [Content Brief]
[2]. Alexander PB, et al. Targeted killing of a mammalian cell based upon its specialized metabolic state. Proc Natl Acad Sci U S A. 2011;108(38):15828-15833. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1956 mL | 10.9782 mL | 21.9563 mL | 54.8908 mL |
| 5 mM | 0.4391 mL | 2.1956 mL | 4.3913 mL | 10.9782 mL | |
| 10 mM | 0.2196 mL | 1.0978 mL | 2.1956 mL | 5.4891 mL | |
| 15 mM | 0.1464 mL | 0.7319 mL | 1.4638 mL | 3.6594 mL | |
| 20 mM | 0.1098 mL | 0.5489 mL | 1.0978 mL | 2.7445 mL | |
| 25 mM | 0.0878 mL | 0.4391 mL | 0.8783 mL | 2.1956 mL | |
| 30 mM | 0.0732 mL | 0.3659 mL | 0.7319 mL | 1.8297 mL | |
| 40 mM | 0.0549 mL | 0.2745 mL | 0.5489 mL | 1.3723 mL | |
| 50 mM | 0.0439 mL | 0.2196 mL | 0.4391 mL | 1.0978 mL | |
| 60 mM | 0.0366 mL | 0.1830 mL | 0.3659 mL | 0.9148 mL | |
| 80 mM | 0.0274 mL | 0.1372 mL | 0.2745 mL | 0.6861 mL | |
| 100 mM | 0.0220 mL | 0.1098 mL | 0.2196 mL | 0.5489 mL |
Qc1 Related Classifications
HY-103391 Related Classifications
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