Dehydroevodiamine hydrochloride (Standard)
Dehydroevodiamine hydrochloride Standard is the analytical standard of Dehydroevodiamine hydrochloride (HY-N6029). This product is intended for research and analytical applications. Dehydroevodiamine hydrochloride is a blood-brain barrier-permeable, orally effective AChE and BACE1 inhibitor (IC50 = 40.96 μM). Dehydroevodiamine hydrochloride is isolated and extracted from Evodia rutaecarpa. Dehydroevodiamine hydrochloride attenuates neurotoxicity through multiple targets by inhibiting BACE1 to block Aβ production, inhibiting AChE activity, scavenging ROS, and suppressing calcium influx. Dehydroevodiamine hydrochloride can be used for research on Alzheimer's disease, cerebral ischemia, vascular dementia, and other cognitive disorder-related diseases.
For research use only. We do not sell to patients.
- CAS No.: 111664-82-5
- Formula: C19H16ClN3O
- Molecular Weight:337.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 111664-82-5
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Molecular Weight 337.80
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Formula C19H16ClN3O
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SMILES
O=C1N2C(N(C)C3=C1C=CC=C3)=C4C(CC2)=C5C=CC=CC5=N4.[H]Cl
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Haji A, et al. Increased feline cerebral blood flow induced by dehydroevodiamine hydrochloride from Evodia rutaecarpa. Journal of natural products. 1994 Mar;57(3):387-9. [Content Brief]
[3]. Shin KY, et al. Dehydroevodiamine·HCl enhances cognitive function in memory-impaired rat models. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. 2017 Jan;21(1):55-64. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dehydroevodiamine hydrochloride (Standard) Related Classifications
HY-N6029R Related Classifications
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Keywords
- Dehydroevodiamine hydrochloride (Standard)
- 111664-82-5
- Reference Standards
- Cholinesterase (ChE)
- Beta-secretase
- Reactive Oxygen Species (ROS)
- Amyloid-β
- Endogenous Metabolite
- acetylcholinesterase
- primary cortical neurons
- vascular dementia
- Evodia rutaecarpa
- Aβ40
- Tg2576 mice
- NMDA receptors
- Alzheimer's disease
- BACE1
- Aβ42
- Inhibitor
- inhibitor
- inhibit