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Cat. No.: HY-N7589

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Demethylcarolignan E

(Synonyms: Carolignan M)

Demethylcarolignan E is a phenylpropanoid ester that can be isolated from the stems of Hibiscus taiwanensi. Demethylcarolignan E has cytotoxicity against human cancer lines A549 and MCF-7 (IC₅₀: <10 μg/mL).

For research use only. We do not sell to patients.

CAS No.: 873694-46-3
Formula: C₃₉H₄₀O₁₃
Molecular Weight:716.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Demethylcarolignan E Chemical Structure

CAS No.: 873694-46-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	>40 μM Compound: 2	Cytotoxicity against human Wnt-dependent DLD1 cells after 24 hrs by fluorometric microculture cytotoxicity assay Cytotoxicity against human Wnt-dependent DLD1 cells after 24 hrs by fluorometric microculture cytotoxicity assay	[PMID: 26026364]
HCT-116	IC₅₀	>39 μM Compound: 2	Cytotoxicity against human Wnt-dependent HCT116 cells after 24 hrs by fluorometric microculture cytotoxicity assay Cytotoxicity against human Wnt-dependent HCT116 cells after 24 hrs by fluorometric microculture cytotoxicity assay	[PMID: 26026364]
HEK293	IC₅₀	24.2 μM Compound: 2	Cytotoxicity against human HEK293 cells after 24 hrs by fluorometric microculture cytotoxicity assay Cytotoxicity against human HEK293 cells after 24 hrs by fluorometric microculture cytotoxicity assay	[PMID: 26026364]
HEK293	IC₅₀	4.5 μM Compound: 2	Inhibition of Wnt/beta-catenin signaling in HEK293 cells stably transfected with TOP reporter gene assessed as TCF/beta-catenin transcriptional activity after 24 hrs by TOP activity/luciferase reporter gene assay Inhibition of Wnt/beta-catenin signaling in HEK293 cells stably transfected with TOP reporter gene assessed as TCF/beta-catenin transcriptional activity after 24 hrs by TOP activity/luciferase reporter gene assay	[PMID: 26026364]
RKO	IC₅₀	23 μM Compound: 2	Cytotoxicity against human Wnt-independent RKO cells after 24 hrs by fluorometric microculture cytotoxicity assay Cytotoxicity against human Wnt-independent RKO cells after 24 hrs by fluorometric microculture cytotoxicity assay	[PMID: 26026364]
SW480	IC₅₀	>40 μM Compound: 2	Cytotoxicity against human Wnt-dependent SW480 cells after 24 hrs by fluorometric microculture cytotoxicity assay Cytotoxicity against human Wnt-dependent SW480 cells after 24 hrs by fluorometric microculture cytotoxicity assay	[PMID: 26026364]

Chemical Information

CAS No. 873694-46-3
Molecular Weight 716.73
Formula C₃₉H₄₀O₁₃
SMILES

O=C(OC[C@H](OC1=CC=C(CCCOC(/C=C/C2=CC=C(O)C(OC)=C2)=O)C=C1O)[C@@H](O)C3=CC=C(O)C(OC)=C3)/C=C/C4=CC=C(O)C(OC)=C4
Synonyms

Carolignan M
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu PL, et al. Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis. Bioorg Med Chem. 2004 May 1;12(9):2193-7. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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