1. Immunology/Inflammation
  2. STING
  3. diABZI-C2-NH2

diABZI-C2-NH2 

Cat. No.: HY-137320
Handling Instructions

diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist.

For research use only. We do not sell to patients.

diABZI-C2-NH2 Chemical Structure

diABZI-C2-NH2 Chemical Structure

CAS No. : 2137975-93-8

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Description

diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist[1].

In Vitro

The author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. Intravenous administration of a diABZI STING agonist to immunocompetent mice with established syngeneic colon tumours elicited strong anti-tumour activity, with complete and lasting regression of tumors[1].
diABZI-C2-NH2 is covalently immobilized on sepharose beads and is used to affinity-capture potential target proteins from a THP1 cell lysate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

721.81

Formula

C₃₆H₄₃N₁₃O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
diABZI-C2-NH2
Cat. No.:
HY-137320
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