2-Hydroxyphenylethanol
Based on 1 Customer Validation
2-Hydroxyphenylethanol is a molecular chaperone that rescues misfolded P123S mutant pendrin, promoting translocation from the cytoplasm to the plasma membrane. 2-Hydroxyphenylethanol can be used for the research of pendred syndrome.
For research use only. We do not sell to patients.
- CAS No.: 7768-28-7
- Formula: C8H10O2
- Molecular Weight:138.17
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Storage:
RT, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>15 mM
Compound: 18
|
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
|
[PMID: 28341401] |
| HEK293 | IC50 |
15 mM
Compound: 18
|
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay
|
[PMID: 28341401] |
2-Hydroxyphenylethanol (Compound 18) (1-30 mM; 12 h) possesses significant molecular chaperone activity to rescue P123S mutant pendrin localization in stable HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7768-28-7
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Appearance Viscous Liquid
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Molecular Weight 138.17
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Formula C8H10O2
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SMILES
OC=1C=CC=CC1CCO
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
RT, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
Purity & Documentation
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Data Sheet (267 KB)
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SDS (614 KB)
- English - EN (614 KB)
- Français - FR (614 KB)
- Deutsch - DE (614 KB)
- Norwegian - NO (614 KB)
- Español - ES (614 KB)
- Swedish - SV (614 KB)
- Italian - IT (614 KB)
- Korean - KR (614 KB)
- Portuguese - PT (614 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)