Akuammine
Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s=2.6 and 0.073 μM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.
For research use only. We do not sell to patients.
- CAS No.: 3512-87-6
- Formula: C22H26N2O4
- Molecular Weight:382.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Chemical Information
-
CAS No. 3512-87-6
-
Molecular Weight 382.45
-
Formula C22H26N2O4
-
SMILES
C/C=C(C1)\[C@H]2[C@]3(C(OC)=O)CO[C@@]45N(C)C6=CC=C(O)C=C6[C@]43CCN1[C@H]5C2
-
Synonyms
(-)-Akuammine; Vincamajoridine
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Akuammine Related Classifications
HY-122189 Related Classifications
Powered by Bioz