ALYREF - Aly/REF export factor Gene

Also Known as ALY; BEF; REF; THOC4; ALY/REF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10189

About ALYREF

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,887,835-81,891,587 (from NCBI)

This gene has 4 transcripts (splice variants), 170 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 44.1), testis (RPKM 33.0) and 25 other tissues.

Summary

The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008]

ALYREF Products (1)

mRNA Protein Name
NM_005782.4 NP_005773.3 THO complex subunit 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables C5-methylcytidine-containing RNA reader activity IDA
IDA: Inferred from direct assay
28418038 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11546874 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA export from nucleus IDA
IDA: Inferred from direct assay
28418038 GOA
involved in mRNA export from nucleus IMP
IMP: Inferred from mutant phenotype
17190602 GOA
Cellular Component GO Annotation Evidence References Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
28418038 GOA
part of exon-exon junction complex IDA
IDA: Inferred from direct assay
16314458 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28418038 GOA
part of transcription export complex IDA
IDA: Inferred from direct assay
15833825 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALYREF Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (108 - 176)

FoP_duplication

FoP_duplication: C-terminal duplication domain of Friend of PRMT1 (202 - 251)

  • 0
  • 100
  • 200
  • 257 a.a.
Protein Preferred Names Protein Names

THO complex subunit 4

  • THO complex 4

ALYREF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ALYREF Q86V81 CHTOP Homo sapiens Q9Y3Y2
Anti Bait CoIP
23299939
Intra
ALYREF Q86V81 CHTOP Homo sapiens Q9Y3Y2
Pull Down
23299939
Intra
ALYREF Q86V81 CHTOP Homo sapiens Q9Y3Y2
Anti Tag CoIP
23299939
Intra
ALYREF Q86V81 DDX39B Homo sapiens Q13838
Anti Bait CoIP
23299939
Intra
ALYREF Q86V81 DDX39B Homo sapiens Q13838
Anti Tag CoIP
23299939
Intra
ALYREF Q86V81 NXF1 Homo sapiens Q9UBU9
Anti Tag CoIP
23299939
Intra
ALYREF Q86V81 NXF1 Homo sapiens Q9UBU9
Pull Down
23299939
Cross
ALYREF Q86V81 mta_hhv8p Human herpesvirus 8 Q2HR75
IF
19850040
Cross
ALYREF Q86V81 mta_hhv8p Human herpesvirus 8 Q2HR75
Pull Down
19850040
Cross: Cross-species interaction Intra: Intraspecies interaction

ALYREF Antibodies

Cat. No. Product Name Application Reactivity
HY-P82334 Aly Antibody (YA2079) WB, IHC-F, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat
HY-P82334A Aly Antibody (YA2079)(PBS only) WB, IHC-F, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Sarcoma

  • Connective And Soft Tissue Neoplasm

  • Tumor Of Soft Tissue And Skeleton

  • Sarcomas

  • Sarcoma - Category
Macular Dystrophy, Patterned, 3

  • Martinique Crinkled Retinal Pigment Epitheliopathy

  • Patterned Macular Dystrophy 3

  • MDPT3

  • Mcrpe
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Spinocerebellar Ataxia 8

  • Spinocerebellar Ataxia Type 8

  • SCA8

  • Ataxia, Spinocerebellar, Type 8
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00639 ALYREF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19247 Alyref Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25736 Alyref Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ALYREF VGNC VGNC:37823
Rattus norvegicus ALYREF RGD RGD:1594679
Felis catus ALYREF VGNC VGNC:59762
Macaca mulatta ALYREF VGNC VGNC:69635
Bos taurus ALYREF VGNC VGNC:25855
Mus musculus ALYREF MGD MGI:1341044
Others ALYREF NCBI