MED8 - mediator complex subunit 8 Gene

Also Known as ARC32

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 112950

About MED8

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:43,383,917-43,389,800 (from NCBI)

This gene has 5 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in thyroid (RPKM 12.7), placenta (RPKM 11.6) and 25 other tissues.

Summary

This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiquitin ligation and protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

MED8 Products (3)

mRNA	Protein	Name
NM_001001653.3	NP_001001653.1	mediator of RNA polymerase II transcription subunit 8 isoform 1
NM_052877.5	NP_443109.2	mediator of RNA polymerase II transcription subunit 8 isoform 3
NM_201542.5	NP_963836.2	mediator of RNA polymerase II transcription subunit 8 isoform 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12149480	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	14638676	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED8 Protein Structure

Med8

0
100
200
268 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 8	activator-recruited cofactor 32 kDa component

MED8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MED8	Q96G25	ELOC	Homo sapiens	Q15369	CoIP	12149480
Intra	MED8	Q96G25	ELOC	Homo sapiens	Q15369	Anti Tag CoIP	12149480
Intra	MED8	Q96G25	ELOB	Homo sapiens	Q15370	CoIP	12149480
Intra	MED8	Q96G25	ELOB	Homo sapiens	Q15370	Y2H	12149480
Intra	MED8	Q96G25	ELOB	Homo sapiens	Q15370	Anti Tag CoIP	12149480

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Phlebotomus Fever	Pappataci Fever Sandfly Fever Sandfly-Borne Phleboviral Disease Sandfly-Borne Arboviral Fever Sandfly-Borne Bunyavirus Fever Three Day Fever Chitral Fever Italy Summer Grippe Italy Summer Grippe Influenza
La Crosse Encephalitis	California Encephalitis California Virus Encephalitis Neuroinvasive California Encephalitis Virus Infection Californian Encephalitis Encephalitis, California California Meningoencephalitis California Encephalitis Virus Infection California Encephalitis Virus Infection Neuroinvasive Disease California Meningoencephalitis Virus Disease California Serogroup Virus Neuroinvasive Disease California Viral Encephalitis Ce - [California Encephalitis] Lac - [La Crosse Encephalitis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08306	MED8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MED8	VGNC	VGNC:63443
Rattus norvegicus	MED8	RGD	RGD:1305552
Mus musculus	MED8	MGD	MGI:1915269
Macaca mulatta	MED8	VGNC	VGNC:74540
Others	MED8	NCBI