TUSC2 - tumor suppressor 2, mitochondrial calcium regulator Gene

Also Known as PAP; FUS1; PDAP2; C3orf11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11334

About TUSC2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,324,909-50,328,223 (from NCBI)

This gene has 6 transcripts (splice variants) and 285 orthologues. Ubiquitous expression in brain (RPKM 15.7), kidney (RPKM 12.1) and 25 other tissues.

Summary

This gene is a highly conserved lung Cancer candidate gene. No Other information about this gene is currently available. [provided by RefSeq, Jul 2008]

TUSC2 Products (1)

mRNA Protein Name
NM_007275.3 NP_009206.1 tumor suppressor candidate 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TUSC2 Protein Structure

TUSC2

TUSC2: Tumour suppressor candidate 2 (1 - 109)

  • 0
  • 100
  • 110 a.a.
Protein Preferred Names Protein Names

tumor suppressor candidate 2

  • PDGFA-associated protein 2

TUSC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TUSC2 O75896 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
TUSC2 O75896 MDFI Homo sapiens Q99750
Validated Y2H
25416956
Intra
TUSC2 O75896 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
TUSC2 O75896 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
TUSC2 O75896 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
Intra
TUSC2 O75896 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra
TUSC2 O75896 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra
TUSC2 O75896 FHL5 Homo sapiens Q5TD97
Validated Y2H
32296183
Intra
TUSC2 O75896 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15274 TUSC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TUSC2 MGD MGI:1931086
Rattus norvegicus TUSC2 RGD RGD:1561664
Macaca mulatta TUSC2 VGNC VGNC:110321
Bos taurus TUSC2 VGNC VGNC:53155
Felis catus TUSC2 VGNC VGNC:97674
Others TUSC2 NCBI