MSRA - methionine sulfoxide reductase A Gene

Also Known as PMSR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4482

About MSRA

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:10,054,292-10,428,891 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 109 orthologues and 3 paralogues. Broad expression in kidney (RPKM 12.0), bone marrow (RPKM 3.1) and 21 other tissues.

Summary

This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

MSRA Products (4)

mRNA Protein Name
NM_001135670.3 NP_001129142.1 mitochondrial peptide methionine sulfoxide reductase isoform b
NM_001135671.3 NP_001129143.1 mitochondrial peptide methionine sulfoxide reductase isoform c
NM_001199729.3 NP_001186658.1 mitochondrial peptide methionine sulfoxide reductase isoform d
NM_012331.5 NP_036463.1 mitochondrial peptide methionine sulfoxide reductase isoform a precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSRA Protein Structure

PMSR

PMSR: Peptide methionine sulfoxide reductase (67 - 220)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

mitochondrial peptide methionine sulfoxide reductase

  • cytosolic methionine-S-sulfoxide reductase

MSRA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MSRA Q9UJ68 UBASH3B Homo sapiens Q8TF42
Anti Tag CoIP
33961781
Intra
MSRA Q9UJ68 FBXL3 Homo sapiens Q9UKT7
Validated Y2H
32296183
Intra
MSRA Q9UJ68 HPCAL4 Homo sapiens Q9UM19
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Intestinal Obstruction

  • Inspissated Milk Syndrome

  • Milk Curd Syndrome
Cataract

  • Cataracts

  • Cat - [Cataract]

  • Cataract Form

  • Lens Opacity

  • Lens Opacities
Parkinson Disease 2, Autosomal Recessive Juvenile

  • Young-Onset Parkinson Disease

  • PARK2

  • Pdj

  • Autosomal Recessive Juvenile Parkinson Disease 2

  • Epdf

  • Parkinson Disease, Juvenile, Type 2

  • Parkinson'S Disease 2

  • Autosomal Recessive Juvenile Parkinson Disease

  • Early-Onset Parkinson Disease

  • Parkinson Disease 2

  • Parkinson Disease, Juvenile, Autosomal Recessive

  • Parkinsonism, Early-Onset, With Diurnal Fluctuation

  • Autosomal Recessive Juvenile Parkinson'S Disease 2

  • Jp

  • Juvenile Parkinsonism

  • Parkinson Disease Autosomal Recessive, Early Onset

  • Parkinsonism, Early Onset, With Diurnal Fluctuation

  • Yopd

  • Autosomal Recessive Early-Onset Parkinson Disease Type 2

  • Chromosome 6-Linked Autosomal Recessive Parkinsonism

  • Early-Onset Parkinsonism With Diurnal Fluctuation

  • Parkinsonism Young Adult Onset

  • Parkinson Disease, Type 2

  • Parkinsonism, Juvenile
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B2188 S-Methyl-L-cysteine 98.0% Unkown
HY-D1256 Msr-blue 99.38% Unkown
HY-RS08725 MSRA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18248 Msr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MSRA VGNC VGNC:31705
Mus musculus MSRA MGD MGI:106916
Rattus norvegicus MSRA RGD RGD:70979
Macaca mulatta MSRA VGNC VGNC:74940
Felis catus MSRA VGNC VGNC:68330
Canis familiaris MSRA VGNC VGNC:43449
Others MSRA NCBI