MAP3K6 - mitogen-activated protein kinase kinase kinase 6 Gene

Also Known as ASK2; MEKK6; MAPKKK6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9064

About MAP3K6

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,355,184-27,366,961 (from NCBI)

This gene has 8 transcripts (splice variants), 193 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 18.7), fat (RPKM 11.6) and 21 other tissues.

Summary

This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

MAP3K6 Products (2)

mRNA Protein Name
NM_001297609.2 NP_001284538.1 mitogen-activated protein kinase kinase kinase 6 isoform 2
NM_004672.5 NP_004663.3 mitogen-activated protein kinase kinase kinase 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9875215 GOA
enables MAP kinase kinase kinase activity IDA
IDA: Inferred from direct assay
9875215 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
9875215 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19935702 GOA
Biological Process GO Annotation Evidence References Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9875215 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K6 Protein Structure

DUF4071

DUF4071: Domain of unknown function (DUF4071) (129 - 507)

Pkinase

Pkinase: Protein kinase domain (653 - 906)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1288 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 6

  • apoptosis signal-regulating kinase 2

MAP3K6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAP3K6 O95382 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
MAP3K6 O95382 YWHAG Homo sapiens P61981
Anti Tag CoIP
33961781
Intra
MAP3K6 O95382 SFN Homo sapiens P31947
Pull Down
32707033
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Diffuse Gastric And Lobular Breast Cancer Syndrome

  • Hereditary Diffuse Gastric Cancer

  • HDGC

  • LBC

  • Familial Diffuse Gastric Cancer

  • Fdgc

  • Hereditary Diffuse Gastric Adenocarcinoma

  • Breast Cancer, Lobular

  • Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate

  • DGLBC

  • Gastric Cancer, Hereditary Diffuse

  • Gastric Cancer, Familial Diffuse Breast Cancer, Lobular

  • Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate

  • E-Cadherin-Associated Hereditary Gastric Cancer

  • Familial Diffuse Cancer Of Stomach

  • Hereditary Diffuse Cancer Of Stomach

  • Gastric Cancer Familial Diffuse

  • Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate

  • Cancer, Gastric, Hereditary Diffuse
Diffuse Gastric Cancer

  • Hereditary Diffuse Gastric Adenocarcinoma

  • Hereditary Diffuse Gastric Cancer

  • Signet Cell Adenocarcinoma

  • Signet Ring Cell Carcinoma

  • Signet Ring Cell Gastric Carcinoma

  • Signet Ring Gastric Carcinoma

  • Fdgc

  • Familial Diffuse Cancer Of Stomach

  • Familial Diffuse Gastric Cancer

  • Gastric Cancer, Familial Diffuse

  • Gastric Cancer, Hereditary Diffuse

  • Hdgc

  • Hereditary Diffuse Cancer Of Stomach

  • Diffuse Gastric Cancer Syndrome

  • Cancer, Gastric, Diffuse

  • Carcinoma, Signet Ring Cell

  • Gastric Signet Ring Carcinoma
Enchondromatosis, Multiple, Ollier Type

  • Ollier Disease

  • Enchondromatosis

  • Dyschondroplasia

  • Osteochondromatosis

  • Multiple Cartilaginous Enchondroses

  • Multiple Enchondromatosis

  • Enchondromatosis With Haemangiomata

  • Enchondromatosis, Multiple

  • Kast'S Syndrome

  • Ollier'S Syndrome

  • Enchondromatosis Multiple

  • ENCHOM

  • Maffucci Disease

  • Olliers Disease

  • Hereditary Multiple Exostoses

  • Chondromatosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08061 MAP3K6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21151 Map3k6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27667 Map3k6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MAP3K6 VGNC VGNC:31199
Rattus norvegicus MAP3K6 RGD RGD:1304625
Macaca mulatta MAP3K6 VGNC VGNC:74496
Felis catus MAP3K6 VGNC VGNC:68160
Mus musculus MAP3K6 MGD MGI:1855691
Canis familiaris MAP3K6 VGNC VGNC:42976
Others MAP3K6 NCBI